TB-Profiler result

Run: SRR6153138
Summary

Run ID: SRR6153138

Sample name:

Date: 19-10-2023 10:38:18

Number of reads: 6099163

Percentage reads mapped: 99.55

Strain: lineage4.5

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.5 Euro-American H;T RD122 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 0.99
gyrA 7892 c.591G>A synonymous_variant 0.99
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 620029 c.139C>T synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169041 c.1572G>A synonymous_variant 0.42
PPE35 2169053 c.1560T>C synonymous_variant 0.88
PPE35 2169059 c.1554G>A synonymous_variant 0.82
PPE35 2169063 p.Met517Thr missense_variant 0.88
PPE35 2169065 p.Ala516Thr missense_variant 0.82
PPE35 2169068 c.1545G>T synonymous_variant 0.82
PPE35 2170568 p.Ile15Met missense_variant 0.99
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2747041 c.558G>A synonymous_variant 0.98
ribD 2987012 c.174C>T synonymous_variant 1.0
ald 3086717 c.-103G>A upstream_gene_variant 0.99
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3878575 c.-68C>T upstream_gene_variant 0.99
clpC1 4038318 p.Pro796Leu missense_variant 0.98
clpC1 4040498 c.207G>A synonymous_variant 0.99
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243760 p.Asp176Glu missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0