TB-Profiler result

Run: SRR6832394
Summary

Run ID: SRR6832394

Sample name:

Date: 04-04-2023 17:23:54

Number of reads: 1331030

Percentage reads mapped: 99.71

Strain: lineage4.8

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2155398 c.713delA frameshift_variant 0.11 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoC 766352 p.Val995Leu missense_variant 0.13
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406943 c.397_398insGC frameshift_variant 0.11
Rv1258c 1406946 p.Ala132Gly missense_variant 0.11
Rv1258c 1406948 c.391_392delGC frameshift_variant 0.11
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102090 p.Phe318Ser missense_variant 0.11
PPE35 2168149 p.Pro822Ser missense_variant 1.0
PPE35 2170481 c.132T>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv2752c 3064822 p.Val457Asp missense_variant 0.12
ald 3086987 p.Gln56His missense_variant 1.0
fprA 3474149 p.Leu48Gln missense_variant 0.11
clpC1 4038264 p.Glu814Val missense_variant 0.11
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4246211 p.Phe993Leu missense_variant 0.1
embB 4246548 p.Pro12Gln missense_variant 0.14
embB 4246555 c.42G>C synonymous_variant 0.15
embB 4246556 p.Ala15Pro missense_variant 0.14
aftB 4268421 p.Leu139Pro missense_variant 0.11
whiB6 4338267 c.255C>T synonymous_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0