TB-Profiler result

Run: DRR034504
Summary

Run ID: DRR034504

Sample name:

Date: 31-03-2023 07:00:50

Number of reads: 1172061

Percentage reads mapped: 98.8

Strain: lineage4.2.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.2 Euro-American H;T;LAM None 1.0
lineage4.2.2 Euro-American (Ural) T;LAM7-TUR None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 7121 p.Pro628Ala missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576077 c.730C>T synonymous_variant 1.0
ccsA 620563 p.Leu225Met missense_variant 0.13
ccsA 620858 p.Val323Ala missense_variant 0.11
rpoC 766381 c.3013delG frameshift_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518447 c.333T>G synonymous_variant 0.12
kasA 2519234 p.Glu374* stop_gained 0.15
folC 2746147 c.1452T>A synonymous_variant 0.12
folC 2746153 p.Phe482Leu missense_variant 0.12
folC 2746246 c.1353C>T synonymous_variant 0.12
pepQ 2860546 c.-128A>G upstream_gene_variant 0.1
Rv2752c 3066280 c.-89C>T upstream_gene_variant 1.0
ald 3086742 c.-78A>C upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339663 p.Trp182* stop_gained 0.1
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3878627 c.-120T>C upstream_gene_variant 0.5
clpC1 4038626 p.Met693Ile missense_variant 0.13
embC 4240492 c.630G>T synonymous_variant 0.14
embA 4242430 c.-803C>T upstream_gene_variant 0.2
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242819 p.Leu986Pro missense_variant 0.18
embA 4243078 c.-155C>G upstream_gene_variant 0.11
embC 4243082 c.3221_3228delATCTGAAC frameshift_variant 0.12
embC 4243092 p.Leu1077Arg missense_variant 0.12
embC 4243095 p.Gly1078Val missense_variant 0.12
embA 4243099 c.-134G>C upstream_gene_variant 0.14
embA 4243102 c.-131G>T upstream_gene_variant 0.14
embC 4243103 p.Thr1081Pro missense_variant 0.14
embC 4243106 p.Arg1082Ser missense_variant 0.14
embC 4243107 c.3245_3246insGTTCAGAT frameshift_variant 0.14
embA 4243339 p.Val36Gly missense_variant 0.11
embA 4244400 p.Leu390Met missense_variant 1.0
embA 4244652 p.Gln474Lys missense_variant 0.17
embA 4244766 p.Glu512Lys missense_variant 0.18
embB 4249533 p.Ala1007Val missense_variant 1.0
aftB 4267766 c.1071G>T synonymous_variant 0.22
whiB6 4338595 c.-75delG upstream_gene_variant 1.0