TB-Profiler result

Run: ERR036204
Summary

Run ID: ERR036204

Sample name:

Date: 31-03-2023 08:29:43

Number of reads: 3702283

Percentage reads mapped: 99.4

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6247 c.1008G>A synonymous_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoB 759831 p.Thr9Pro missense_variant 0.36
rpoC 762836 c.-534C>G upstream_gene_variant 0.39
rpoC 767305 p.Tyr1312* stop_gained 0.32
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777399 p.Thr361Arg missense_variant 0.14
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.24
inhA 1674892 p.Asn231Asp missense_variant 0.22
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
PPE35 2169320 p.Leu431Phe missense_variant 0.22
PPE35 2169866 c.747G>C synonymous_variant 0.35
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.13
eis 2715586 c.-254G>C upstream_gene_variant 0.67
Rv2752c 3064741 p.Gly484Ala missense_variant 0.27
thyA 3073806 c.666C>G synonymous_variant 0.26
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
fprA 3474601 p.Arg199Gly missense_variant 0.32
rpoA 3878238 p.Asp90Glu missense_variant 0.21
clpC1 4039932 p.Gly258Val missense_variant 0.14
embC 4239842 c.-21C>A upstream_gene_variant 0.19
embC 4242425 p.Arg855Gly missense_variant 0.19
embC 4242476 p.Pro872Ala missense_variant 0.24
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.32
embC 4242827 p.Leu989Val missense_variant 0.19
aftB 4267880 c.957C>T synonymous_variant 1.0
ethA 4327672 c.-199G>A upstream_gene_variant 0.2
ethR 4327974 p.Met142Ile missense_variant 1.0
ethR 4327975 p.Gln143Lys missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448505 c.3_*1408del frameshift_variant&start_lost&splice_region_variant 1.0