TB-Profiler result

Run: ERR036247
Summary

Run ID: ERR036247

Sample name:

Date: 31-03-2023 08:31:36

Number of reads: 5379333

Percentage reads mapped: 95.36

Strain: lineage4.3.4.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.4 Euro-American (LAM) LAM RD174 1.0
lineage4.3.4.2 Euro-American (LAM) LAM1;LAM4;LAM11 RD174 1.0
lineage4.3.4.2.1 Euro-American (LAM) LAM11 RD174 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6140 p.Val301Leu missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 762836 c.-534C>G upstream_gene_variant 0.48
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777399 p.Thr361Arg missense_variant 0.26
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
atpE 1461019 c.-26C>A upstream_gene_variant 0.18
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472138 n.293C>T non_coding_transcript_exon_variant 0.22
rrs 1472147 n.302G>A non_coding_transcript_exon_variant 0.21
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.22
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.22
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.2
rrs 1472708 n.863T>A non_coding_transcript_exon_variant 0.17
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.35
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.38
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.38
rrs 1472786 n.941C>T non_coding_transcript_exon_variant 0.33
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.31
rrs 1472803 n.958T>C non_coding_transcript_exon_variant 0.28
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.31
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.27
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.29
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.37
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.31
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.25
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.24
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.24
rrs 1473001 n.1156G>T non_coding_transcript_exon_variant 0.25
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.24
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.23
rrs 1473009 n.1164T>A non_coding_transcript_exon_variant 0.24
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.1
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.1
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.11
rrl 1474380 n.723G>T non_coding_transcript_exon_variant 0.27
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.23
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.19
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.2
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.29
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.29
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.22
rrl 1475866 n.2209T>A non_coding_transcript_exon_variant 0.14
rrl 1475869 n.2212C>T non_coding_transcript_exon_variant 0.13
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.11
rrl 1476229 n.2572C>G non_coding_transcript_exon_variant 0.1
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.1
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.1
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.11
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.26
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.29
rrl 1476353 n.2696G>A non_coding_transcript_exon_variant 0.34
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.34
rrl 1476359 n.2702C>T non_coding_transcript_exon_variant 0.36
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.39
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.4
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.48
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.5
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.44
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.44
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.35
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.33
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.32
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.28
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.15
rrl 1476592 n.2935G>A non_coding_transcript_exon_variant 0.16
rrl 1476605 n.2948C>T non_coding_transcript_exon_variant 0.16
rrl 1476608 n.2951C>A non_coding_transcript_exon_variant 0.15
rrl 1476614 n.2957A>G non_coding_transcript_exon_variant 0.16
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.16
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.13
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.13
rrl 1476637 n.2980C>A non_coding_transcript_exon_variant 0.13
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169320 p.Leu431Phe missense_variant 0.18
PPE35 2169866 c.747G>C synonymous_variant 0.26
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.15
folC 2747263 c.336C>A synonymous_variant 0.2
pepQ 2859381 c.1038C>G synonymous_variant 0.21
ribD 2987307 p.Ala157Pro missense_variant 0.18
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474601 p.Arg199Gly missense_variant 0.26
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0
fbiB 3642734 c.1200G>C synonymous_variant 0.17
alr 3840719 c.702A>G synonymous_variant 1.0
rpoA 3878238 p.Asp90Glu missense_variant 0.2
ddn 3987013 p.Gly57Ala missense_variant 0.33
clpC1 4038287 c.2418C>T synonymous_variant 1.0
clpC1 4038857 c.1848C>A synonymous_variant 0.17
clpC1 4039932 p.Gly258Val missense_variant 0.28
embC 4239842 c.-21C>A upstream_gene_variant 0.18
embC 4242476 p.Pro872Ala missense_variant 0.25
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.37
embC 4242827 p.Leu989Val missense_variant 0.2
ubiA 4269529 p.Ala102Gly missense_variant 0.2
ethA 4327672 c.-199G>A upstream_gene_variant 0.24
whiB6 4338187 p.Ser112Phe missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0