TB-Profiler result

Run: ERR10796569
Summary

Run ID: ERR10796569

Sample name:

Date: 31-03-2023 11:11:41

Number of reads: 2011

Percentage reads mapped: 99.36

Strain: lineage4.9

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.6 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 1.0 kanamycin, capreomycin, aminoglycosides, amikacin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 8858 c.1557T>C synonymous_variant 1.0
gyrA 8870 c.1569G>C synonymous_variant 1.0
gyrA 8873 c.1572A>G synonymous_variant 1.0
gyrA 8897 c.1596T>C synonymous_variant 1.0
gyrA 8903 c.1602T>C synonymous_variant 1.0
gyrA 8915 c.1614A>G synonymous_variant 1.0
gyrA 8942 c.1641G>C synonymous_variant 1.0
gyrA 8945 c.1644G>C synonymous_variant 1.0
gyrA 8946 c.1645T>C synonymous_variant 1.0
gyrA 8957 c.1656C>T synonymous_variant 1.0
gyrA 8967 p.Ala556Lys missense_variant 1.0
rpoB 761132 c.1326G>C synonymous_variant 1.0
rpoB 761133 c.1327T>C synonymous_variant 1.0
rpoB 761147 c.1341C>T synonymous_variant 1.0
rpoB 761150 c.1344A>T synonymous_variant 1.0
rpoB 761165 c.1359G>C synonymous_variant 1.0
rpoB 761171 c.1365C>T synonymous_variant 1.0
rpoB 761178 p.Ser458Thr missense_variant 1.0
rpoB 761186 p.Glu460Asp missense_variant 1.0
rpoB 761189 c.1383T>C synonymous_variant 1.0
rpoB 761195 c.1389G>C synonymous_variant 1.0
rpoB 761198 c.1392G>C synonymous_variant 1.0
rpoB 761219 c.1413G>C synonymous_variant 1.0
rpoB 762158 c.2352G>C synonymous_variant 1.0
rpoB 762167 c.2361T>C synonymous_variant 1.0
rpoB 762176 c.2370T>C synonymous_variant 1.0
rpoB 762185 c.2379G>C synonymous_variant 1.0
rpoB 762194 c.2388G>C synonymous_variant 1.0
rpoB 762233 c.2427G>C synonymous_variant 1.0
rpoB 762236 c.2430G>C synonymous_variant 1.0
rpoB 762245 c.2439G>C synonymous_variant 1.0
rpoB 762275 c.2469C>T synonymous_variant 1.0
rpoB 762284 c.2478G>C synonymous_variant 1.0
rpoB 762293 c.2487T>C synonymous_variant 1.0
rpoB 762296 c.2490G>C synonymous_variant 1.0
rpoC 762959 c.-411G>C upstream_gene_variant 1.0
rpoC 762962 c.-408C>T upstream_gene_variant 1.0
rpoC 762995 c.-375G>T upstream_gene_variant 1.0
rpoC 763031 c.-339T>G upstream_gene_variant 1.0
rpoC 763034 c.-336C>G upstream_gene_variant 1.0
rpoC 763040 c.-330C>G upstream_gene_variant 1.0
rpoC 763070 c.-300T>C upstream_gene_variant 1.0
rpoC 763082 c.-288C>T upstream_gene_variant 1.0
rpoC 763088 c.-282C>G upstream_gene_variant 1.0
rpoC 763094 c.-276G>C upstream_gene_variant 1.0
rpoC 763115 c.-255T>C upstream_gene_variant 1.0
rpoC 763127 c.-243G>C upstream_gene_variant 1.0
rpoC 763136 c.-234C>T upstream_gene_variant 1.0
rpoC 763145 c.-225G>A upstream_gene_variant 1.0
rpoC 763157 c.-213G>T upstream_gene_variant 1.0
rpoC 763166 c.-204A>G upstream_gene_variant 1.0
rpoC 763468 c.99G>C synonymous_variant 1.0
rpoC 763486 c.117T>C synonymous_variant 1.0
rpoC 763492 c.123G>C synonymous_variant 1.0
rpoC 763528 c.159G>A synonymous_variant 1.0
rpoC 763531 c.162G>T synonymous_variant 1.0
rpoC 763546 c.177A>G synonymous_variant 1.0
rpoC 763570 c.201G>C synonymous_variant 1.0
rpoC 763594 c.225C>T synonymous_variant 1.0
rpoC 763633 c.264T>C synonymous_variant 1.0
rpoC 763657 c.288G>A synonymous_variant 1.0
rpoC 763660 c.291T>G synonymous_variant 1.0
rpoC 763666 c.297G>C synonymous_variant 1.0
rpoC 763669 c.300C>G synonymous_variant 1.0
rpoC 763675 c.306C>G synonymous_variant 1.0
rpoC 764387 c.1018T>C synonymous_variant 1.0
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 1.0
rpoC 764611 c.1242G>T synonymous_variant 1.0
rpoC 764626 c.1257C>T synonymous_variant 1.0
rpoC 764632 c.1263T>C synonymous_variant 1.0
rpoC 764650 c.1281G>T synonymous_variant 1.0
rpoC 764668 c.1299C>T synonymous_variant 1.0
rpoC 764692 c.1323C>T synonymous_variant 1.0
rpoC 766996 c.3627C>T synonymous_variant 1.0
rpoC 767002 c.3633G>C synonymous_variant 1.0
rpoC 767008 c.3639G>A synonymous_variant 1.0
rpoC 767023 c.3654C>T synonymous_variant 1.0
rpoC 767044 c.3675G>C synonymous_variant 1.0
rpoC 767080 c.3711G>C synonymous_variant 1.0
rpoC 767098 c.3729T>C synonymous_variant 1.0
rpoC 767104 c.3735C>G synonymous_variant 1.0
rpoC 767107 c.3738C>T synonymous_variant 1.0
rpoC 767119 c.3750A>G synonymous_variant 1.0
rpoC 767125 c.3756G>C synonymous_variant 1.0
rpoC 767134 c.3765C>T synonymous_variant 1.0
rpoC 767138 c.3769C>T synonymous_variant 1.0
rpoC 767149 c.3780C>T synonymous_variant 1.0
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 1.0
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 1.0
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 1.0
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 1.0
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 1.0
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 1.0
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 1.0
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 1.0
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 1.0
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 1.0
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.5
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.6
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.4
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.6
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.75
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.67
rrs 1472674 n.829T>G non_coding_transcript_exon_variant 0.67
rrs 1472675 n.830T>A non_coding_transcript_exon_variant 0.67
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.67
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.67
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.5
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.67
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.67
rrs 1472754 n.909G>T non_coding_transcript_exon_variant 0.4
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 1.0
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 1.0
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 1.0
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 1.0
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 1.0
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 1.0
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 1.0
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 1.0
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 1.0
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 1.0
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 1.0
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.75
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.75
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.75
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 1.0
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 1.0
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 1.0
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.75
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 1.0
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 1.0
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 1.0
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.83
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.83
rrs 1473270 n.1425G>A non_coding_transcript_exon_variant 0.5
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.75
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 1.0
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 1.0
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 1.0
rrl 1474507 n.850G>C non_coding_transcript_exon_variant 1.0
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 1.0
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.67
rrl 1474743 n.1086T>G non_coding_transcript_exon_variant 0.67
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 1.0
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 1.0
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 1.0
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 1.0
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 1.0
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 1.0
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.3
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.3
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.42
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.36
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.44
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.44
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.53
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.74
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.68
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.71
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.71
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.55
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.44
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.5
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.5
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.5
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 1.0
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 1.0
rpsA 1833589 c.48A>C synonymous_variant 1.0
rpsA 1833595 c.54T>G synonymous_variant 1.0
rpsA 1833596 p.Ser19Ala missense_variant 1.0
rpsA 1833604 c.63C>T synonymous_variant 1.0
rpsA 1833616 c.75A>T synonymous_variant 1.0
rpsA 1833619 c.78A>C synonymous_variant 1.0
rpsA 1833625 c.84A>G synonymous_variant 1.0
rpsA 1833664 c.123C>G synonymous_variant 1.0
rpsA 1833676 c.135A>G synonymous_variant 1.0
rpsA 1833679 c.138G>T synonymous_variant 1.0
rpsA 1833685 c.144G>C synonymous_variant 1.0
rpsA 1833691 c.150G>A synonymous_variant 1.0
rpsA 1833694 c.153G>T synonymous_variant 1.0
rpsA 1833697 c.156C>T synonymous_variant 1.0
rpsA 1833700 c.159C>T synonymous_variant 1.0
rpsA 1833709 c.168C>T synonymous_variant 1.0
rpsA 1833811 c.270G>T synonymous_variant 1.0
rpsA 1833823 c.282G>A synonymous_variant 1.0
rpsA 1833832 c.291G>A synonymous_variant 1.0
rpsA 1833838 c.297G>C synonymous_variant 1.0
rpsA 1833841 c.300C>G synonymous_variant 1.0
rpsA 1833847 c.306C>G synonymous_variant 1.0
rpsA 1833856 c.315A>G synonymous_variant 1.0
rpsA 1833862 c.321G>T synonymous_variant 1.0
rpsA 1833874 c.333T>G synonymous_variant 1.0
rpsA 1833886 c.345C>G synonymous_variant 1.0
rpsA 1833894 p.Ala118Glu missense_variant 1.0
rpsA 1833928 c.387G>C synonymous_variant 1.0
rpsA 1833949 c.408T>C synonymous_variant 1.0
rpsA 1833961 c.420C>G synonymous_variant 1.0
rpsA 1833970 c.429G>T synonymous_variant 1.0
rpsA 1833979 c.438T>C synonymous_variant 1.0
rpsA 1833991 c.450C>G synonymous_variant 1.0
rpsA 1834000 c.459G>C synonymous_variant 1.0
rpsA 1834009 c.468C>T synonymous_variant 1.0
rpsA 1834012 c.471G>C synonymous_variant 1.0
rpsA 1834015 c.474G>C synonymous_variant 1.0
rpsA 1834021 c.480C>T synonymous_variant 1.0
rpsA 1834030 c.489C>G synonymous_variant 1.0
rpsA 1834033 c.492C>T synonymous_variant 1.0
rpsA 1834375 c.834G>C synonymous_variant 1.0
rpsA 1834396 c.855G>C synonymous_variant 1.0
rpsA 1834429 c.888C>T synonymous_variant 1.0
rpsA 1834438 c.897C>T synonymous_variant 1.0
rpsA 1834451 c.910T>C synonymous_variant 1.0
rpsA 1834456 c.915T>G synonymous_variant 1.0
rpsA 1834468 c.927A>G synonymous_variant 1.0
rpsA 1834477 c.936C>T synonymous_variant 1.0
rpsA 1834489 c.948T>C synonymous_variant 1.0
rpsA 1834519 c.978G>C synonymous_variant 1.0
rpsA 1834520 p.Ala327Ser missense_variant 1.0
rpsA 1834528 c.987T>C synonymous_variant 1.0
rpsA 1834534 c.993C>T synonymous_variant 1.0
rpsA 1834543 c.1002C>G synonymous_variant 1.0
rpsA 1834546 c.1005T>C synonymous_variant 1.0
rpsA 1834552 c.1011G>T synonymous_variant 1.0
rpsA 1834555 c.1014T>G synonymous_variant 1.0
rpsA 1834557 p.Ala339Gly missense_variant 1.0
rpsA 1834606 c.1065C>T synonymous_variant 1.0
rpsA 1834609 c.1068T>C synonymous_variant 1.0
rpoA 3878184 c.324C>T synonymous_variant 1.0
rpoA 3878193 c.315T>C synonymous_variant 1.0
rpoA 3878196 p.Glu104Ala missense_variant 1.0
rpoA 3878205 c.303T>C synonymous_variant 1.0
rpoA 3878217 c.291A>G synonymous_variant 1.0
rpoA 3878259 c.249G>C synonymous_variant 1.0
rpoA 3878271 c.237T>C synonymous_variant 0.75
rpoA 3878283 p.Glu75Asp missense_variant 1.0
rpoA 3878292 c.216T>C synonymous_variant 1.0
rpoA 3878298 c.210A>G synonymous_variant 1.0
rpoA 3878301 c.207C>G synonymous_variant 1.0
clpC1 4038989 c.1716T>C synonymous_variant 1.0
clpC1 4038997 c.1708T>C synonymous_variant 1.0
clpC1 4039022 c.1683A>G synonymous_variant 1.0
clpC1 4039070 c.1635G>C synonymous_variant 1.0
clpC1 4039121 c.1584T>C synonymous_variant 1.0
clpC1 4039142 c.1563A>G synonymous_variant 1.0
clpC1 4039145 c.1560G>C synonymous_variant 1.0
clpC1 4039169 p.Glu512Asp missense_variant 1.0
clpC1 4039172 c.1533A>G synonymous_variant 1.0
clpC1 4039178 c.1527G>C synonymous_variant 1.0
clpC1 4039183 c.1522T>C synonymous_variant 1.0
clpC1 4039190 c.1515C>T synonymous_variant 1.0
clpC1 4039262 c.1443C>T synonymous_variant 1.0
clpC1 4039265 c.1440C>T synonymous_variant 1.0
clpC1 4039271 c.1434G>A synonymous_variant 1.0
clpC1 4039283 c.1422C>T synonymous_variant 1.0
clpC1 4039286 c.1417_1419delCTTinsTTA synonymous_variant 1.0
clpC1 4039289 c.1416T>C synonymous_variant 1.0
clpC1 4039292 c.1413C>T synonymous_variant 1.0
clpC1 4039304 c.1401G>A synonymous_variant 1.0
clpC1 4040009 c.696C>G synonymous_variant 1.0
clpC1 4040015 c.690G>C synonymous_variant 1.0
clpC1 4040021 c.684A>T synonymous_variant 1.0
clpC1 4040024 c.681A>G synonymous_variant 1.0
clpC1 4040033 c.672G>C synonymous_variant 1.0
clpC1 4040048 c.657C>T synonymous_variant 1.0
clpC1 4040087 c.618G>C synonymous_variant 1.0
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 1.0
clpC1 4040093 c.612C>G synonymous_variant 1.0