TB-Profiler result

Run: ERR11049874
Summary

Run ID: ERR11049874

Sample name:

Date: 02-04-2023 00:47:46

Number of reads: 3330395

Percentage reads mapped: 99.66

Strain: lineage4.7

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.7 Euro-American (mainly T) T1;T5 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 9647 c.2346C>G synonymous_variant 0.19
mshA 576108 p.Ala254Gly missense_variant 0.13
mshA 576442 p.Cys365Trp missense_variant 0.36
mshA 576450 p.Pro368Arg missense_variant 0.25
mshA 576453 p.Val369Gly missense_variant 0.4
mshA 576456 p.Val370Gly missense_variant 0.22
mshA 576606 p.Ala420Gly missense_variant 0.37
rpoB 760797 p.Asp331His missense_variant 1.0
rpoC 764367 p.Gly333Ala missense_variant 0.14
rpoC 764534 p.Arg389Gly missense_variant 0.22
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.31
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474294 n.637C>G non_coding_transcript_exon_variant 1.0
fabG1 1673553 p.Asp38Glu missense_variant 0.51
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.21
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.39
eis 2714275 p.Arg353Pro missense_variant 1.0
Rv2752c 3064823 p.Val457Leu missense_variant 0.17
thyX 3067944 p.Val1Gly missense_variant 0.24
ald 3086638 c.-182G>A upstream_gene_variant 1.0
ald 3087816 p.Cys333Gly missense_variant 0.24
fbiD 3339734 p.Ala206Gly missense_variant 0.4
fbiD 3339751 p.Ala212Pro missense_variant 0.29
fprA 3474213 p.Lys69Asn missense_variant 0.12
whiB7 3568431 c.249C>G synonymous_variant 0.4
fbiB 3642182 c.648G>A synonymous_variant 1.0
rpoA 3878641 c.-134C>G upstream_gene_variant 1.0
embC 4240409 p.Pro183Ala missense_variant 0.18
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.43
embB 4247015 p.Ser168Ala missense_variant 0.22
embB 4247020 c.507C>G synonymous_variant 0.21
embB 4248328 c.1815G>C synonymous_variant 0.26
embB 4249732 c.3219C>G synonymous_variant 1.0
whiB6 4338200 p.Asp108His missense_variant 0.17
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338676 c.-155T>G upstream_gene_variant 0.99