TB-Profiler result

Run: ERR11050085
Summary

Run ID: ERR11050085

Sample name:

Date: 02-04-2023 10:59:01

Number of reads: 3363790

Percentage reads mapped: 99.64

Strain: lineage4.8

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 9647 c.2346C>G synonymous_variant 0.23
mshA 576113 p.Arg256Gly missense_variant 0.25
mshA 576116 p.Ala257Pro missense_variant 0.15
mshA 576442 p.Cys365Trp missense_variant 0.28
mshA 576465 p.Ala373Gly missense_variant 0.33
mshA 576489 p.Val381Gly missense_variant 0.27
rpoC 764367 p.Gly333Ala missense_variant 0.41
rpoC 764534 p.Arg389Gly missense_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.21
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1476058 n.2401T>G non_coding_transcript_exon_variant 0.22
fabG1 1673553 p.Asp38Glu missense_variant 0.33
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
PPE35 2170035 p.Val193Gly missense_variant 0.18
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.27
pepQ 2860159 p.Ala87Gly missense_variant 0.12
Rv2752c 3064823 p.Val457Leu missense_variant 0.24
ald 3086999 c.180C>G synonymous_variant 1.0
ald 3087816 p.Cys333Gly missense_variant 0.16
fbiD 3339751 p.Ala212Pro missense_variant 0.22
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
fprA 3474213 p.Lys69Asn missense_variant 0.11
whiB7 3568428 c.252A>G synonymous_variant 0.4
alr 3840357 p.Leu355Arg missense_variant 0.19
clpC1 4039729 p.Asp326Asn missense_variant 1.0
embC 4240409 p.Pro183Ala missense_variant 0.12
embC 4241086 c.1224G>A synonymous_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.44
embB 4247016 p.Ser168Trp missense_variant 0.2
embB 4247020 c.507C>G synonymous_variant 0.21
embB 4248328 c.1815G>C synonymous_variant 0.21
aftB 4267400 c.1437G>C synonymous_variant 0.2
ethA 4327461 p.Leu5Phe missense_variant 1.0
whiB6 4338200 p.Asp108His missense_variant 0.23
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0