TB-Profiler result

Run: ERR11050433
Summary

Run ID: ERR11050433

Sample name:

Date: 03-04-2023 04:08:21

Number of reads: 4575259

Percentage reads mapped: 99.62

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 8680 p.Ala460Val missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.21
rpoC 764367 p.Gly333Ala missense_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.15
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781676 c.117C>T synonymous_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2167771 p.Ser948Cys missense_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.22
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.69
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
Rv3083 3448500 c.-4A>G upstream_gene_variant 1.0
Rv3083 3448501 c.-3G>T upstream_gene_variant 1.0
whiB7 3568431 c.249C>G synonymous_variant 0.25
rpoA 3878613 c.-106A>C upstream_gene_variant 0.31
rpoA 3878618 c.-111A>C upstream_gene_variant 0.27
rpoA 3878631 c.-124C>G upstream_gene_variant 0.25
rpoA 3878637 c.-130G>C upstream_gene_variant 0.2
rpoA 3878641 c.-134C>G upstream_gene_variant 0.38
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243700 c.468C>T synonymous_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.26
embB 4246584 p.Arg24Pro missense_variant 0.17
embB 4249354 c.2841G>C synonymous_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0