TB-Profiler result

Run: ERR11050680
Summary

Run ID: ERR11050680

Sample name:

Date: 03-04-2023 16:26:36

Number of reads: 3137238

Percentage reads mapped: 99.42

Strain: lineage4.3.3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.3 Euro-American (LAM) LAM;T RD115 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5723 p.Ala162Ser missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8040 p.Gly247Ser missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9647 c.2346C>G synonymous_variant 0.21
mshA 575240 c.-108G>A upstream_gene_variant 1.0
mshA 576113 p.Arg256Gly missense_variant 0.29
mshA 576456 p.Val370Gly missense_variant 0.25
mshA 576483 p.Val379Gly missense_variant 0.21
mshA 576613 c.1266A>C synonymous_variant 0.33
mshA 576616 c.1269G>C synonymous_variant 0.31
mshA 576618 p.His424Pro missense_variant 0.24
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.24
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
fabG1 1673553 p.Asp38Glu missense_variant 0.32
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918066 p.Ala43Pro missense_variant 0.2
PPE35 2170065 p.Ala183Gly missense_variant 0.33
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518919 p.Gly269Ser missense_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.27
thyX 3067946 c.-1C>G upstream_gene_variant 0.22
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.6
fbiD 3339746 p.Ala210Gly missense_variant 1.0
fbiD 3339751 p.Ala212Pro missense_variant 0.26
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474212 p.Lys69Thr missense_variant 0.16
rpoA 3878597 c.-90G>C upstream_gene_variant 0.33
rpoA 3878601 c.-94C>G upstream_gene_variant 0.5
rpoA 3878641 c.-134C>G upstream_gene_variant 0.73
clpC1 4038287 c.2418C>T synonymous_variant 1.0
embC 4240409 p.Pro183Ala missense_variant 0.37
embC 4242182 p.Ala774Ser missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.35
embB 4246584 p.Arg24Pro missense_variant 0.15
embB 4247016 p.Ser168Trp missense_variant 0.21
embB 4248328 c.1815G>C synonymous_variant 0.26
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0