TB-Profiler result

Run: ERR11068532
Summary

Run ID: ERR11068532

Sample name:

Date: 06-04-2023 16:28:52

Number of reads: 4198084

Percentage reads mapped: 99.42

Strain: lineage4.1.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 1.0
mshA 575679 p.Asn111Ser missense_variant 1.0
mshA 576116 p.Ala257Pro missense_variant 0.5
mshA 576119 p.Ala258Pro missense_variant 0.4
ccsA 619849 c.-42G>A upstream_gene_variant 0.15
ccsA 619939 p.Ala17Thr missense_variant 0.15
ccsA 620049 c.159G>A synonymous_variant 0.29
rpoB 760106 c.300G>A synonymous_variant 1.0
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304226 c.1296C>T synonymous_variant 0.14
fbiC 1304230 p.Pro434Ser missense_variant 0.12
Rv1258c 1406991 p.Gly117Asp missense_variant 0.33
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
inhA 1674381 c.180G>A synonymous_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918108 p.Asp57Tyr missense_variant 0.13
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
kasA 2519049 p.Gly312Asp missense_variant 0.13
folC 2746593 p.Pro336Ser missense_variant 1.0
pepQ 2860150 p.Ala90Val missense_variant 0.2
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339345 c.228C>G synonymous_variant 0.13
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568431 c.249C>G synonymous_variant 0.33
fbiB 3642711 c.1177C>T synonymous_variant 0.11
embC 4241702 p.Arg614Cys missense_variant 0.25
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4248329 p.Met606Leu missense_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0