TB-Profiler result

Run: ERR11081282
Summary

Run ID: ERR11081282

Sample name:

Date: 08-04-2023 14:37:07

Number of reads: 557174

Percentage reads mapped: 99.55

Strain: lineage4.5

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.5 Euro-American H;T RD122 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Asp missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 0.96 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7892 c.591G>A synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491003 p.Val74Ala missense_variant 0.12
fgd1 491030 p.Pro83His missense_variant 0.12
mshA 576111 p.Ala255Gly missense_variant 0.18
ccsA 619788 c.-103G>T upstream_gene_variant 1.0
ccsA 620029 c.139C>T synonymous_variant 1.0
rpoC 764996 p.Val543Met missense_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406101 p.Pro414Ser missense_variant 1.0
Rv1258c 1406536 p.Gly269Ser missense_variant 0.12
embR 1416662 p.Arg229His missense_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154533 p.Ser527Ala missense_variant 0.12
PPE35 2168575 p.Ala680Thr missense_variant 0.12
PPE35 2170333 c.277_279delATG conservative_inframe_deletion 0.12
PPE35 2170568 p.Ile15Met missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289312 c.-71G>A upstream_gene_variant 0.11
ahpC 2726549 c.357C>T synonymous_variant 0.11
Rv2752c 3065088 c.1104A>G synonymous_variant 0.12
thyX 3067587 p.Pro120Leu missense_variant 0.17
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiA 3640850 p.Glu103Gly missense_variant 0.11
fbiA 3641453 p.Arg304Gln missense_variant 0.17
fbiB 3641700 p.Cys56Arg missense_variant 0.11
fbiB 3641715 p.Val61Phe missense_variant 0.12
rpoA 3877842 c.666A>T synonymous_variant 0.12
rpoA 3878575 c.-68C>T upstream_gene_variant 1.0
clpC1 4038318 p.Pro796Leu missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244409 p.Trp393Arg missense_variant 0.11
aftB 4267735 p.Gly368Ser missense_variant 0.12
aftB 4268279 c.558G>A synonymous_variant 0.15
whiB6 4338595 c.-75delG upstream_gene_variant 1.0