TB-Profiler result

Run: ERR11081439
Summary

Run ID: ERR11081439

Sample name:

Date: 08-04-2023 21:45:22

Number of reads: 7036824

Percentage reads mapped: 99.67

Strain: lineage4.7

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.7 Euro-American (mainly T) T1;T5 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 760314 p.Val170Phe missense_variant 0.41 rifampicin
rpoB 761101 p.Gln432Pro missense_variant 0.6 rifampicin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.26
rpoB 760719 p.Val305Leu missense_variant 0.39
rpoC 764817 p.Val483Ala missense_variant 0.11
rpoC 764819 p.Trp484Gly missense_variant 0.23
rpoC 765618 p.Glu750Ala missense_variant 0.24
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775994 c.2487C>A synonymous_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474294 n.637C>G non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2155258 p.Gly285Val missense_variant 1.0
PPE35 2168587 p.Ile676Val missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4249732 c.3219C>G synonymous_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0