TB-Profiler result

Run: ERR11243483

Summary

Run ID: ERR11243483

Sample name:

Date: 21-04-2023 19:20:19

Number of reads: 2031654

Percentage reads mapped: 99.65

Strain: lineage4.8

Drug-resistance: Sensitive


Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 7130 p.Arg631Ser missense_variant 0.12
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7955 c.654G>T synonymous_variant 0.11
gyrA 9305 c.2004C>A synonymous_variant 0.13
fgd1 491027 p.Asn82Thr missense_variant 0.24
mshA 575214 c.-134C>A upstream_gene_variant 0.12
rpoB 760556 c.750G>A synonymous_variant 0.11
rpoC 767014 c.3645G>T synonymous_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
inhA 1674474 c.273G>A synonymous_variant 0.12
inhA 1674537 c.336C>A synonymous_variant 0.11
rpsA 1834986 c.1445G>T stop_lost&splice_region_variant 0.11
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918210 p.Ala91Ser missense_variant 0.13
katG 2155704 c.408C>T synonymous_variant 0.11
PPE35 2168149 p.Pro822Ser missense_variant 1.0
PPE35 2168255 c.2358G>A synonymous_variant 0.11
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2746354 c.1244dupA frameshift_variant 0.13
folC 2747707 c.-109C>A upstream_gene_variant 0.13
thyA 3074532 c.-61C>T upstream_gene_variant 0.1
ald 3086987 p.Gln56His missense_variant 1.0
fprA 3474882 c.876C>T synonymous_variant 0.1
clpC1 4039729 p.Asp326Asn missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244224 p.Ala331Val missense_variant 0.1
embA 4245723 p.Gly831Arg missense_variant 0.2
embB 4245863 c.-651C>T upstream_gene_variant 0.11
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0