TB-Profiler result

Run: ERR11466164
Summary

Run ID: ERR11466164

Sample name:

Date: 08-01-2024 03:46:14

Number of reads: 2019272

Percentage reads mapped: 99.71

Strain: lineage4.9.1;lineage4.1.1.3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 0.14
lineage4.9 Euro-American (H37Rv-like) T1 None 0.84
lineage4.9.1 Euro-American (H37Rv-like) T1 None 0.82
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 0.17
lineage4.1.1.3 Euro-American (X-type) X1;X3 RD193 0.15
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 8978 c.1677C>T synonymous_variant 0.8
rpoC 765150 p.Gly594Glu missense_variant 0.18
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1417416 c.-69G>A upstream_gene_variant 0.89
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289138 p.Leu35Arg missense_variant 0.77
eis 2715179 p.Ala52Ser missense_variant 0.17
ald 3086788 c.-32T>C upstream_gene_variant 0.11
fbiD 3339385 p.Asp90Asn missense_variant 0.97
clpC1 4038201 p.Ala835Val missense_variant 0.89
embB 4249408 c.2895G>A synonymous_variant 0.16
whiB6 4338595 c.-75delG upstream_gene_variant 1.0