TB-Profiler result

Run: ERR11466258
Summary

Run ID: ERR11466258

Sample name:

Date: 08-01-2024 05:20:24

Number of reads: 4213976

Percentage reads mapped: 99.77

Strain: lineage4.8.1;lineage4.7

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.7 Euro-American (mainly T) T1;T5 None 0.28
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.73
lineage4.8.1 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.73
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.66
rrl 1474294 n.637C>G non_coding_transcript_exon_variant 0.31
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 0.77
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
thyX 3067956 c.-11A>C upstream_gene_variant 0.24
fbiD 3339040 c.-78T>C upstream_gene_variant 0.71
fbiB 3642874 p.Leu447Arg missense_variant 0.73
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4247775 p.Arg421Gln missense_variant 0.72
embB 4249732 c.3219C>G synonymous_variant 0.22
aftB 4267427 c.1410G>A synonymous_variant 0.27
whiB6 4338595 c.-75delG upstream_gene_variant 1.0