TB-Profiler result

Run: ERR2228832
Summary

Run ID: ERR2228832

Sample name:

Date: 31-03-2023 16:22:23

Number of reads: 939519

Percentage reads mapped: 99.61

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576325 c.978G>T synonymous_variant 0.12
ccsA 620033 p.Ala48Val missense_variant 0.13
rpoC 763894 c.525A>G synonymous_variant 0.11
rpoC 764253 p.Arg295Pro missense_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777264 p.Leu406Pro missense_variant 0.12
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673357 c.-83G>A upstream_gene_variant 0.12
fabG1 1673359 c.-81T>C upstream_gene_variant 0.12
fabG1 1673361 c.-79C>G upstream_gene_variant 0.12
fabG1 1673380 c.-60C>G upstream_gene_variant 0.13
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154948 c.1164G>T synonymous_variant 0.13
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2170357 p.Ala86Ser missense_variant 0.11
PPE35 2170359 p.Gln85Arg missense_variant 0.11
PPE35 2170363 p.Glu84Gln missense_variant 0.11
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2715031 p.Cys101Phe missense_variant 0.18
folC 2747679 c.-81C>A upstream_gene_variant 0.12
folC 2747742 c.-145dupA upstream_gene_variant 0.14
fbiB 3641678 c.144T>G synonymous_variant 0.11
alr 3840894 p.Leu176Arg missense_variant 0.1
embC 4240538 p.Pro226Thr missense_variant 0.13
embA 4242442 c.-791G>T upstream_gene_variant 0.11
embC 4242513 p.Val884Ala missense_variant 0.12
embA 4242643 c.-590C>T upstream_gene_variant 1.0
aftB 4267603 p.Arg412Gly missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0