TB-Profiler result

Run: ERR2228905
Summary

Run ID: ERR2228905

Sample name:

Date: 31-03-2023 16:25:29

Number of reads: 940533

Percentage reads mapped: 99.55

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
ccsA 620807 p.Asn306Ile missense_variant 0.14
rpoB 759713 c.-94C>T upstream_gene_variant 0.12
rpoC 763079 c.-291C>T upstream_gene_variant 0.12
rpoC 764514 p.Phe382Ser missense_variant 0.25
rpoC 764636 p.Asp423Tyr missense_variant 0.13
rpoC 765277 c.1908G>T synonymous_variant 0.11
rpoC 765302 p.Glu645Gln missense_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776080 p.Ala801Ser missense_variant 0.15
mmpL5 776081 c.2400G>A synonymous_variant 0.15
mmpL5 779283 c.-803G>A upstream_gene_variant 0.12
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
Rv1258c 1406282 c.1059G>A synonymous_variant 0.18
embR 1417217 c.130delA frameshift_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673380 c.-60C>G upstream_gene_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102944 c.99C>A synonymous_variant 0.12
PPE35 2167745 p.Thr956Arg missense_variant 0.18
PPE35 2167865 c.2748G>C synonymous_variant 0.11
PPE35 2167868 c.2745A>C synonymous_variant 0.11
PPE35 2168728 p.Gly629Arg missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2290194 c.-953G>T upstream_gene_variant 0.2
ribD 2987451 c.614_616delGTG disruptive_inframe_deletion 0.13
rpoA 3878644 c.-137G>T upstream_gene_variant 1.0
clpC1 4039971 p.Lys245Arg missense_variant 0.12
clpC1 4040144 c.561G>C synonymous_variant 0.11
clpC1 4040311 p.Thr132Ala missense_variant 0.11
embC 4240899 p.Leu346Pro missense_variant 0.11
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243548 p.Phe106Leu missense_variant 0.12
embB 4248884 p.Asn791Asp missense_variant 0.11
aftB 4267903 p.Val312Leu missense_variant 0.29
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448497 c.-6_*1408del transcript_ablation 1.0