TB-Profiler result

Run: ERR2229191
Summary

Run ID: ERR2229191

Sample name:

Date: 31-03-2023 16:48:10

Number of reads: 1359567

Percentage reads mapped: 99.16

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7769 c.468C>T synonymous_variant 1.0
rpoB 760463 c.657C>T synonymous_variant 0.12
rpoC 765887 p.Phe840Ile missense_variant 0.12
rpoC 766917 p.Arg1183Pro missense_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775756 p.Thr909Ala missense_variant 0.15
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1474627 n.970G>T non_coding_transcript_exon_variant 0.14
fabG1 1673380 c.-60C>G upstream_gene_variant 0.18
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2167965 p.Ala883Gly missense_variant 0.26
PPE35 2167967 c.2646A>C synonymous_variant 0.19
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2169902 c.711G>C synonymous_variant 0.12
PPE35 2170048 p.Leu189Val missense_variant 0.29
PPE35 2170053 p.Thr187Ser missense_variant 0.27
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518330 p.Met72Ile missense_variant 0.11
Rv2752c 3066131 p.Leu21Met missense_variant 0.17
fbiD 3339703 p.Thr196Pro missense_variant 0.15
alr 3840422 p.Arg333Ser missense_variant 0.11
alr 3841546 c.-126C>A upstream_gene_variant 0.14
rpoA 3877869 p.Lys213Asn missense_variant 0.12
embC 4242152 p.Gly764Ser missense_variant 0.12
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246548 p.Pro12Gln missense_variant 0.3
embB 4246555 c.42G>C synonymous_variant 0.4
embB 4246556 p.Ala15Pro missense_variant 0.3
embB 4246584 p.Arg24Pro missense_variant 0.15
embB 4246610 p.Ala33Ser missense_variant 0.12
embB 4247072 p.Gly187Arg missense_variant 0.14
aftB 4267895 p.Phe314Leu missense_variant 0.18
ethR 4327811 p.Gln88Pro missense_variant 0.1
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0