TB-Profiler result

Run: ERR2229271
Summary

Run ID: ERR2229271

Sample name:

Date: 31-03-2023 16:55:06

Number of reads: 1150705

Percentage reads mapped: 99.19

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576100 p.Asp251Glu missense_variant 0.14
rpoB 761457 p.Pro551Ser missense_variant 0.13
rpoB 762119 c.2313C>T synonymous_variant 1.0
rpoC 767113 c.3744G>C synonymous_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
embR 1416971 p.Ala126Val missense_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1475049 n.1392C>G non_coding_transcript_exon_variant 0.11
fabG1 1673380 c.-60C>G upstream_gene_variant 0.25
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2169902 p.Leu237Phe missense_variant 0.18
PPE35 2169910 p.Asn235Tyr missense_variant 0.15
PPE35 2170048 p.Leu189Val missense_variant 0.27
PPE35 2170053 p.Thr187Ser missense_variant 0.31
PPE35 2170147 p.Ser156Ala missense_variant 0.16
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714928 c.405C>A synonymous_variant 0.12
folC 2746261 c.1338G>A synonymous_variant 0.14
ribD 2987230 p.Ala131Glu missense_variant 0.2
ribD 2987484 p.Ala216Ser missense_variant 0.14
ald 3087725 c.906C>A synonymous_variant 0.14
alr 3841546 c.-126C>A upstream_gene_variant 0.23
clpC1 4040411 c.294T>G synonymous_variant 0.11
embC 4241765 p.Ala635Pro missense_variant 0.29
embC 4242030 p.Leu723Gln missense_variant 0.13
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242648 p.Leu929Arg missense_variant 0.14
embC 4242773 p.Leu971Met missense_variant 0.12
embB 4246544 p.Thr11Pro missense_variant 0.12
embB 4246548 p.Pro12Gln missense_variant 0.24
embB 4246555 c.42G>C synonymous_variant 0.19
embB 4246556 p.Ala15Pro missense_variant 0.19
embB 4247028 p.Leu172Arg missense_variant 0.13
aftB 4267692 p.Ile382Asn missense_variant 0.12
aftB 4267827 p.Arg337Gln missense_variant 0.25
aftB 4268715 p.Leu41Pro missense_variant 0.18
aftB 4268731 c.106C>A synonymous_variant 0.15
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0