TB-Profiler result

Run: ERR2229284
Summary

Run ID: ERR2229284

Sample name:

Date: 31-03-2023 16:56:23

Number of reads: 1038937

Percentage reads mapped: 98.97

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6345 p.Gly369Asp missense_variant 0.12
gyrB 6532 p.Ser431Arg missense_variant 0.2
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.17
ccsA 619899 c.9G>A synonymous_variant 0.15
rpoB 761152 p.Leu449Gln missense_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
Rv1258c 1406557 p.Trp262Arg missense_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1474491 n.834A>T non_coding_transcript_exon_variant 0.12
rrl 1475774 n.2117C>T non_coding_transcript_exon_variant 0.13
fabG1 1673346 c.-94C>G upstream_gene_variant 0.11
fabG1 1673380 c.-60C>G upstream_gene_variant 0.24
inhA 1674102 c.-100C>A upstream_gene_variant 0.2
rpsA 1834346 c.807_808dupTG frameshift_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102075 p.Met323Lys missense_variant 0.13
ndh 2102644 c.399A>G synonymous_variant 0.17
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2168810 c.1803T>C synonymous_variant 0.11
PPE35 2169609 p.Gly335Ala missense_variant 0.14
PPE35 2169717 p.Asn299Ile missense_variant 0.12
PPE35 2169725 c.888T>C synonymous_variant 0.12
PPE35 2169902 c.711G>C synonymous_variant 0.11
PPE35 2170048 p.Leu189Val missense_variant 0.16
PPE35 2170053 p.Thr187Ser missense_variant 0.16
PPE35 2170189 p.Glu142Gln missense_variant 0.17
Rv1979c 2222524 p.Gly214Asp missense_variant 0.13
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518288 c.174C>A synonymous_variant 0.14
kasA 2518809 p.Lys232Arg missense_variant 0.11
folC 2746241 c.1355_1357delCCG disruptive_inframe_deletion 0.15
Rv2752c 3065245 p.Ser316Leu missense_variant 0.14
fbiD 3339749 p.Val211Asp missense_variant 0.15
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
Rv3236c 3612205 c.912C>A synonymous_variant 0.12
rpoA 3878482 p.Leu9Arg missense_variant 0.4
clpC1 4038774 p.Asp644Ala missense_variant 0.18
panD 4044118 p.Leu55Pro missense_variant 0.12
embC 4240275 p.Pro138Leu missense_variant 0.12
embC 4242018 p.Glu719Gly missense_variant 0.14
embC 4242020 p.Val720Leu missense_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246544 p.Thr11Pro missense_variant 0.22
embB 4246548 p.Pro12Gln missense_variant 0.2
embB 4246555 c.42G>C synonymous_variant 0.2
embB 4246556 p.Ala15Pro missense_variant 0.2
embB 4246989 p.Ala159Val missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448497 c.-6_*1408del transcript_ablation 1.0