TB-Profiler result

Run: ERR2229386
Summary

Run ID: ERR2229386

Sample name:

Date: 2024-04-16T04:31:45.528708

Number of reads: 344473

Percentage reads mapped: 98.53

Median coverage: 7.0

Strain: lineage4.8;lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 0.28
lineage4.9 Euro-American (H37Rv-like) None 0.8
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
fabG1 1673380 c.-60C>G upstream_gene_variant 0.46 ethionamide
isoniazid
PPE35 2170048 p.Leu189Val missense_variant 0.63 pyrazinamide
PPE35 2170053 p.Thr187Ser missense_variant 0.61 pyrazinamide
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance