TB-Profiler result

Run: ERR2446570
Summary

Run ID: ERR2446570

Sample name:

Date: 19-10-2023 19:00:22

Number of reads: NA

Percentage reads mapped: NA

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.97
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6250 c.1011A>G synonymous_variant 0.13
gyrB 6280 c.1041T>C synonymous_variant 0.14
gyrB 6286 c.1047T>C synonymous_variant 0.13
gyrA 6307 c.-995T>G upstream_gene_variant 0.15
gyrA 7132 c.-170T>G upstream_gene_variant 0.15
gyrA 7165 c.-137C>G upstream_gene_variant 0.14
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7484 c.183T>C synonymous_variant 0.14
gyrA 7664 c.363T>C synonymous_variant 0.14
gyrA 8619 c.1318T>C synonymous_variant 0.14
gyrA 8642 c.1341A>G synonymous_variant 0.18
gyrA 8672 c.1371A>G synonymous_variant 0.18
gyrA 8693 c.1392T>C synonymous_variant 0.17
gyrA 8711 c.1410A>C synonymous_variant 0.15
gyrA 8714 c.1413A>G synonymous_variant 0.15
mshA 575893 c.546C>G synonymous_variant 0.15
ccsA 620319 c.429C>G synonymous_variant 0.13
ccsA 620340 c.450C>G synonymous_variant 0.13
rpoB 760223 c.417T>C synonymous_variant 0.13
rpoB 760235 c.429T>C synonymous_variant 0.14
rpoB 760283 c.477G>C synonymous_variant 0.14
rpoB 760805 c.999G>C synonymous_variant 0.13
rpoB 760859 c.1053T>C synonymous_variant 0.13
rpoB 760862 c.1056G>C synonymous_variant 0.13
rpoB 760886 c.1080A>G synonymous_variant 0.16
rpoB 760925 c.1119T>C synonymous_variant 0.15
rpoB 761015 c.1209G>C synonymous_variant 0.13
rpoB 761027 c.1221A>G synonymous_variant 0.15
rpoB 761057 c.1251G>C synonymous_variant 0.15
rpoB 761102 c.1296A>G synonymous_variant 0.2
rpoB 761129 c.1323G>C synonymous_variant 0.14
rpoB 761132 c.1326G>T synonymous_variant 0.22
rpoB 761133 c.1327T>C synonymous_variant 0.22
rpoB 761150 c.1344A>C synonymous_variant 0.2
rpoB 761153 c.1347G>C synonymous_variant 0.14
rpoB 761165 c.1359G>C synonymous_variant 0.21
rpoB 761180 c.1374A>C synonymous_variant 0.22
rpoB 761189 c.1383T>C synonymous_variant 0.21
rpoB 761195 c.1389G>C synonymous_variant 0.19
rpoB 761249 c.1443A>G synonymous_variant 0.17
rpoB 761255 c.1449T>G synonymous_variant 0.15
rpoB 761261 c.1455G>T synonymous_variant 0.16
rpoB 761327 c.1521A>G synonymous_variant 0.14
rpoB 761510 c.1704T>C synonymous_variant 0.14
rpoB 761537 c.1731C>G synonymous_variant 0.15
rpoB 761570 c.1764T>C synonymous_variant 0.17
rpoB 761573 c.1767C>G synonymous_variant 0.17
rpoB 761579 c.1773G>C synonymous_variant 0.17
rpoB 761588 c.1782C>T synonymous_variant 0.14
rpoB 761606 c.1800C>G synonymous_variant 0.13
rpoB 761612 c.1806G>C synonymous_variant 0.13
rpoB 761615 c.1809A>C synonymous_variant 0.13
rpoB 762131 c.2325C>G synonymous_variant 0.14
rpoB 762143 c.2337T>C synonymous_variant 0.13
rpoB 762167 c.2361T>C synonymous_variant 0.14
rpoB 762176 c.2370T>C synonymous_variant 0.14
rpoB 762185 c.2379G>C synonymous_variant 0.14
rpoB 762233 c.2427G>C synonymous_variant 0.16
rpoB 762284 c.2478G>C synonymous_variant 0.14
rpoB 762293 c.2487T>C synonymous_variant 0.14
rpoB 762317 c.2511A>G synonymous_variant 0.16
rpoB 762329 c.2523G>C synonymous_variant 0.16
rpoB 762338 c.2532T>C synonymous_variant 0.14
rpoB 762347 c.2541T>C synonymous_variant 0.15
rpoC 762857 c.-513C>G upstream_gene_variant 0.13
rpoC 762860 c.-510G>C upstream_gene_variant 0.12
rpoC 762995 c.-375G>T upstream_gene_variant 0.16
rpoC 763028 c.-342T>C upstream_gene_variant 0.16
rpoC 763034 c.-336C>G upstream_gene_variant 0.14
rpoC 763040 c.-330C>G upstream_gene_variant 0.18
rpoC 763070 c.-300T>C upstream_gene_variant 0.18
rpoC 763085 c.-285C>G upstream_gene_variant 0.2
rpoC 763115 c.-255T>C upstream_gene_variant 0.16
rpoC 763444 c.75T>C synonymous_variant 0.16
rpoC 763456 c.87A>G synonymous_variant 0.15
rpoC 763528 c.159G>A synonymous_variant 0.13
rpoC 763546 c.177A>G synonymous_variant 0.16
rpoC 763570 c.201G>C synonymous_variant 0.14
rpoC 763573 c.204G>C synonymous_variant 0.13
rpoC 763636 c.267T>C synonymous_variant 0.14
rpoC 763660 c.291T>G synonymous_variant 0.18
rpoC 763675 c.306C>G synonymous_variant 0.16
rpoC 763702 c.333C>G synonymous_variant 0.17
rpoC 763717 c.348T>C synonymous_variant 0.19
rpoC 763723 c.354G>C synonymous_variant 0.17
rpoC 763741 c.372C>T synonymous_variant 0.19
rpoC 763744 c.375G>C synonymous_variant 0.19
rpoC 763765 c.396T>C synonymous_variant 0.13
rpoC 763774 c.405G>C synonymous_variant 0.13
rpoC 763807 c.438T>C synonymous_variant 0.21
rpoC 763835 p.Ala156Met missense_variant 0.16
rpoC 763858 c.489A>G synonymous_variant 0.17
rpoC 763872 p.Gly168Ala missense_variant 0.15
rpoC 764446 c.1077T>C synonymous_variant 0.14
rpoC 764449 c.1080G>C synonymous_variant 0.13
rpoC 764452 c.1083T>C synonymous_variant 0.14
rpoC 764458 c.1089G>C synonymous_variant 0.14
rpoC 764461 c.1092A>G synonymous_variant 0.15
rpoC 764497 c.1128A>G synonymous_variant 0.14
rpoC 764521 c.1152T>C synonymous_variant 0.15
rpoC 764539 c.1170C>G synonymous_variant 0.14
rpoC 764566 c.1197C>G synonymous_variant 0.14
rpoC 764575 c.1206T>G synonymous_variant 0.15
rpoC 764752 c.1383G>C synonymous_variant 0.14
rpoC 764764 c.1395T>C synonymous_variant 0.16
rpoC 764809 c.1440C>T synonymous_variant 0.17
rpoC 764815 c.1446A>G synonymous_variant 0.18
rpoC 764858 c.1489T>C synonymous_variant 0.16
rpoC 764888 c.1519T>C synonymous_variant 0.17
rpoC 764911 c.1542A>G synonymous_variant 0.21
rpoC 764932 c.1563C>A synonymous_variant 0.19
rpoC 764935 c.1566T>C synonymous_variant 0.17
rpoC 764948 c.1579T>C synonymous_variant 0.17
rpoC 764968 c.1599T>C synonymous_variant 0.2
rpoC 764995 c.1626C>G synonymous_variant 0.13
rpoC 765019 c.1650A>G synonymous_variant 0.19
rpoC 765034 c.1665T>C synonymous_variant 0.18
rpoC 765040 c.1671T>C synonymous_variant 0.17
rpoC 765041 c.1672T>C synonymous_variant 0.16
rpoC 765499 c.2130C>G synonymous_variant 0.15
rpoC 765541 c.2172C>G synonymous_variant 0.14
rpoC 765700 c.2331T>C synonymous_variant 0.13
rpoC 765753 p.Asp795Ala missense_variant 0.12
rpoC 765937 c.2568T>C synonymous_variant 0.19
rpoC 766027 c.2658G>C synonymous_variant 0.15
rpoC 766054 c.2685C>G synonymous_variant 0.14
rpoC 766082 p.Ala905Gln missense_variant 0.21
rpoC 766096 c.2727G>C synonymous_variant 0.18
rpoC 766129 c.2760C>G synonymous_variant 0.17
rpoC 766141 c.2772C>T synonymous_variant 0.14
rpoC 766142 c.2773C>T synonymous_variant 0.14
rpoC 766447 c.3078T>C synonymous_variant 0.13
rpoC 766462 c.3093G>C synonymous_variant 0.13
rpoC 766657 c.3288A>G synonymous_variant 0.19
rpoC 766672 c.3303T>C synonymous_variant 0.18
rpoC 766726 c.3357T>C synonymous_variant 0.17
rpoC 766738 c.3369G>C synonymous_variant 0.18
rpoC 766765 c.3396A>C synonymous_variant 0.17
rpoC 766774 c.3405T>C synonymous_variant 0.16
rpoC 766795 c.3426C>T synonymous_variant 0.15
rpoC 766804 c.3435A>G synonymous_variant 0.2
rpoC 766861 c.3492G>C synonymous_variant 0.21
rpoC 766864 c.3495G>C synonymous_variant 0.21
rpoC 766894 c.3525T>C synonymous_variant 0.19
rpoC 766895 c.3526T>C synonymous_variant 0.21
rpoC 766900 c.3531T>C synonymous_variant 0.21
rpoC 766933 c.3564A>G synonymous_variant 0.17
rpoC 766945 c.3576A>G synonymous_variant 0.15
rpoC 767014 c.3645G>C synonymous_variant 0.13
rpoC 767033 p.Ser1222Arg missense_variant 0.18
rpoC 767059 c.3690T>G synonymous_variant 0.17
rpoC 767062 c.3693C>A synonymous_variant 0.17
rpoC 767098 c.3729T>C synonymous_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781649 c.90T>C synonymous_variant 0.15
rpsL 781655 c.96T>C synonymous_variant 0.15
rpsL 781728 c.169T>C synonymous_variant 0.13
rpsL 781736 c.177T>C synonymous_variant 0.13
rpsL 781865 c.306G>C synonymous_variant 0.13
rpsL 781868 c.309T>C synonymous_variant 0.13
rpsL 781871 c.312G>C synonymous_variant 0.13
rpsL 781898 c.339A>T synonymous_variant 0.13
rpsL 781929 p.Gly124Ser missense_variant 0.14
rplC 800648 c.-161A>T upstream_gene_variant 0.14
rplC 800654 c.-155T>C upstream_gene_variant 0.14
rplC 800693 c.-116A>G upstream_gene_variant 0.14
rplC 800703 c.-106T>C upstream_gene_variant 0.16
rplC 800715 c.-94A>C upstream_gene_variant 0.15
rplC 800720 c.-89T>C upstream_gene_variant 0.15
rplC 800723 c.-86C>G upstream_gene_variant 0.15
rplC 800747 c.-62C>G upstream_gene_variant 0.18
fbiC 1304546 p.Val539Ala missense_variant 0.13
fbiC 1304553 c.1623C>T synonymous_variant 0.14
fbiC 1304559 p.Glu543Asp missense_variant 0.14
fbiC 1304565 c.1635C>G synonymous_variant 0.14
fbiC 1304568 c.1638T>C synonymous_variant 0.14
fbiC 1304580 c.1650T>C synonymous_variant 0.17
fbiC 1304613 c.1683T>C synonymous_variant 0.19
fbiC 1304634 c.1704C>G synonymous_variant 0.15
fbiC 1304640 c.1710A>C synonymous_variant 0.15
fbiC 1304869 c.1939C>T synonymous_variant 0.14
fbiC 1304907 c.1977C>G synonymous_variant 0.16
fbiC 1304910 c.1980G>C synonymous_variant 0.14
fbiC 1304916 c.1986T>C synonymous_variant 0.16
fbiC 1304928 c.1998T>C synonymous_variant 0.19
fbiC 1304937 c.2007G>C synonymous_variant 0.2
fbiC 1304958 c.2028T>G synonymous_variant 0.16
fbiC 1304994 c.2064A>G synonymous_variant 0.13
fbiC 1304995 p.Leu689Met missense_variant 0.13
fbiC 1305006 c.2076A>G synonymous_variant 0.13
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.21
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.17
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.21
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.22
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.26
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.18
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.14
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.2
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.17
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.17
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.14
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.16
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.16
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.15
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.15
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.17
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.18
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.15
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.19
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.19
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.15
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.21
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.21
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.23
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.23
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.23
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.26
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.24
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.25
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.25
rrl 1475401 n.1745C>T non_coding_transcript_exon_variant 0.16
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.26
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.17
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.18
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.16
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.16
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.18
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.14
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.15
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.18
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.17
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.16
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.15
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.15
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.14
rpsA 1834513 c.972C>G synonymous_variant 0.16
rpsA 1834528 c.987T>C synonymous_variant 0.16
rpsA 1834540 c.999G>C synonymous_variant 0.14
rpsA 1834546 c.1005T>C synonymous_variant 0.16
rpsA 1834555 c.1014T>G synonymous_variant 0.15
rpsA 1834609 c.1068T>C synonymous_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2155691 c.421T>C synonymous_variant 0.13
katG 2155695 c.417C>G synonymous_variant 0.13
katG 2155704 c.408C>G synonymous_variant 0.14
katG 2155716 c.396T>G synonymous_variant 0.13
katG 2155722 c.390G>C synonymous_variant 0.13
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289680 c.-439T>C upstream_gene_variant 1.0
Rv2752c 3065210 c.982T>C synonymous_variant 0.15
Rv2752c 3065262 c.930G>A synonymous_variant 0.14
thyX 3067457 c.489C>G synonymous_variant 0.14
thyX 3067475 c.471A>G synonymous_variant 0.16
thyX 3067490 c.456C>G synonymous_variant 0.15
thyX 3067493 c.453A>G synonymous_variant 0.15
thyX 3067515 p.Ser144Thr missense_variant 0.15
thyX 3067530 p.Ala139Ser missense_variant 0.16
thyX 3067545 p.Glu134Ala missense_variant 0.17
thyX 3067549 p.Thr133Ala missense_variant 0.16
thyX 3067556 p.His130Gln missense_variant 0.16
thyX 3067850 c.96A>C synonymous_variant 0.15
thyX 3067869 p.Thr26Ser missense_variant 0.13
rpoA 3877587 c.921A>G synonymous_variant 0.14
rpoA 3877613 p.Ile299Val missense_variant 0.15
rpoA 3877638 c.870T>C synonymous_variant 0.12
rpoA 3877782 c.726T>C synonymous_variant 0.13
rpoA 3878271 c.237T>C synonymous_variant 0.14
rpoA 3878292 c.216T>C synonymous_variant 0.13
rpoA 3878385 c.123C>G synonymous_variant 0.14
rpoA 3878415 c.93C>T synonymous_variant 0.16
clpC1 4038623 c.2082A>G synonymous_variant 0.17
clpC1 4038640 p.Asp689Asn missense_variant 0.16
clpC1 4038653 c.2052C>T synonymous_variant 0.19
clpC1 4038658 p.Lys683Gln missense_variant 0.19
clpC1 4038661 p.Ser682Thr missense_variant 0.19
clpC1 4038662 c.2043T>C synonymous_variant 0.19
clpC1 4038671 c.2034T>C synonymous_variant 0.19
clpC1 4038683 c.2022T>C synonymous_variant 0.2
clpC1 4038695 c.2010C>G synonymous_variant 0.15
clpC1 4038704 c.2001T>C synonymous_variant 0.2
clpC1 4038707 c.1998C>G synonymous_variant 0.19
clpC1 4038710 c.1995G>C synonymous_variant 0.15
clpC1 4038713 c.1992T>C synonymous_variant 0.21
clpC1 4038773 c.1932T>C synonymous_variant 0.18
clpC1 4038782 c.1923G>C synonymous_variant 0.17
clpC1 4038812 c.1893T>C synonymous_variant 0.15
clpC1 4038908 c.1797C>G synonymous_variant 0.13
clpC1 4038914 c.1791G>C synonymous_variant 0.16
clpC1 4038923 c.1782A>G synonymous_variant 0.16
clpC1 4038953 c.1752A>G synonymous_variant 0.16
clpC1 4038956 c.1749T>C synonymous_variant 0.15
clpC1 4038965 c.1740T>C synonymous_variant 0.15
clpC1 4038971 c.1734T>C synonymous_variant 0.15
clpC1 4038974 c.1731T>C synonymous_variant 0.16
clpC1 4038989 c.1716T>C synonymous_variant 0.15
clpC1 4038997 c.1708T>C synonymous_variant 0.13
clpC1 4039004 c.1701C>G synonymous_variant 0.15
clpC1 4039022 c.1683A>G synonymous_variant 0.16
clpC1 4039103 c.1602T>C synonymous_variant 0.12
clpC1 4039274 c.1431G>C synonymous_variant 0.14
clpC1 4039339 p.Thr456Pro missense_variant 0.14
clpC1 4039364 c.1341C>G synonymous_variant 0.19
clpC1 4039610 c.1095G>C synonymous_variant 0.16
clpC1 4039616 c.1089G>C synonymous_variant 0.17
clpC1 4039622 c.1083C>T synonymous_variant 0.13
clpC1 4039694 c.1011G>C synonymous_variant 0.15
clpC1 4039724 c.981A>G synonymous_variant 0.15
clpC1 4039729 p.Asp326Asn missense_variant 0.87
clpC1 4039790 c.915C>G synonymous_variant 0.13
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4248130 c.1617G>C synonymous_variant 0.15
whiB6 4338595 c.-75delG upstream_gene_variant 1.0