TB-Profiler result

Run: ERR245653
Summary

Run ID: ERR245653

Sample name:

Date: 31-03-2023 18:12:17

Number of reads: 13346973

Percentage reads mapped: 99.65

Strain: lineage4.9.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
lineage4.9.1 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6934 p.Gln565His missense_variant 0.27
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7493 c.192C>T synonymous_variant 0.29
gyrA 8978 c.1677C>T synonymous_variant 1.0
mshA 576751 p.Lys468Asn missense_variant 0.19
ccsA 620407 p.Pro173Ala missense_variant 0.22
rpoB 759620 c.-187A>C upstream_gene_variant 0.34
rpoC 762836 c.-534C>G upstream_gene_variant 0.24
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1417233 c.115C>T synonymous_variant 0.26
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1473343 n.1498G>T non_coding_transcript_exon_variant 0.16
rrl 1474380 n.723G>T non_coding_transcript_exon_variant 0.14
rrl 1476408 n.2751G>C non_coding_transcript_exon_variant 0.18
inhA 1674952 p.Pro251Ala missense_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102891 p.Phe51Ser missense_variant 0.19
PPE35 2169866 c.747G>C synonymous_variant 0.23
Rv1979c 2223145 p.Arg7Lys missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289138 p.Leu35Arg missense_variant 1.0
pncA 2289448 c.-207G>A upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.26
eis 2714569 p.Ala255Gly missense_variant 0.19
eis 2715586 c.-254G>C upstream_gene_variant 0.29
ahpC 2725954 c.-239C>T upstream_gene_variant 0.32
Rv2752c 3064741 p.Gly484Ala missense_variant 0.27
Rv2752c 3067191 c.-1000G>A upstream_gene_variant 1.0
fbiD 3339385 p.Asp90Asn missense_variant 1.0
fprA 3475280 p.Val425Gly missense_variant 0.22
fbiB 3641955 p.Gly141Arg missense_variant 0.28
clpC1 4039932 p.Gly258Val missense_variant 0.18
embC 4241056 c.1194C>G synonymous_variant 0.26
embC 4241429 p.Phe523Val missense_variant 0.36
embC 4241456 p.Ala532Pro missense_variant 0.3
embC 4242476 p.Pro872Ala missense_variant 0.18
embC 4242822 p.Val987Gly missense_variant 0.37
embC 4242827 p.Leu989Val missense_variant 0.18
embA 4244375 c.1143C>G synonymous_variant 0.29
ubiA 4269529 p.Ala102Gly missense_variant 0.23
ethA 4327672 c.-199G>A upstream_gene_variant 0.18
whiB6 4338595 c.-75delG upstream_gene_variant 1.0