TB-Profiler result

Run: ERR245685
Summary

Run ID: ERR245685

Sample name:

Date: 31-03-2023 18:14:53

Number of reads: 11217239

Percentage reads mapped: 99.64

Strain: lineage4.9.1

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
lineage4.9.1 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7493 c.192C>T synonymous_variant 0.29
gyrA 8978 c.1677C>T synonymous_variant 1.0
ccsA 620748 c.858T>G synonymous_variant 0.25
rpoB 759620 c.-187A>C upstream_gene_variant 0.36
rpoC 762836 c.-534C>G upstream_gene_variant 0.21
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474380 n.723G>T non_coding_transcript_exon_variant 0.18
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.19
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102891 p.Phe51Ser missense_variant 0.17
PPE35 2169379 p.Phe412Val missense_variant 0.24
PPE35 2169866 c.747G>C synonymous_variant 0.24
PPE35 2170090 p.Pro175Ser missense_variant 0.31
Rv1979c 2223145 p.Arg7Lys missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289138 p.Leu35Arg missense_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.16
eis 2714569 p.Ala255Gly missense_variant 0.2
eis 2715586 c.-254G>C upstream_gene_variant 0.4
folC 2746186 c.1413G>C synonymous_variant 0.18
Rv2752c 3064552 p.Arg547Pro missense_variant 0.16
Rv2752c 3064741 p.Gly484Ala missense_variant 0.29
Rv2752c 3065618 p.Gly192Arg missense_variant 0.21
Rv2752c 3067191 c.-1000G>A upstream_gene_variant 1.0
thyA 3073817 p.Gln219Glu missense_variant 0.26
fbiD 3339385 p.Asp90Asn missense_variant 1.0
fbiD 3339550 p.Gly145Trp missense_variant 0.18
Rv3083 3449673 p.Tyr390* stop_gained 0.18
Rv3236c 3611982 p.Ala379Pro missense_variant 0.43
fbiB 3641955 p.Gly141Arg missense_variant 0.35
clpC1 4038857 c.1848C>A synonymous_variant 0.17
clpC1 4039932 p.Gly258Val missense_variant 0.26
embC 4239870 p.Thr3Asn missense_variant 0.22
embC 4241056 c.1194C>G synonymous_variant 0.24
embC 4241456 p.Ala532Pro missense_variant 0.39
embC 4242476 p.Pro872Ala missense_variant 0.23
embC 4242822 p.Val987Gly missense_variant 0.25
ubiA 4269529 p.Ala102Gly missense_variant 0.21
ethA 4327672 c.-199G>A upstream_gene_variant 0.21
whiB6 4338595 c.-75delG upstream_gene_variant 1.0