TB-Profiler result

Run: ERR245786
Summary

Run ID: ERR245786

Sample name:

Date: 31-03-2023 18:21:28

Number of reads: 14327101

Percentage reads mapped: 99.4

Strain: lineage4.1.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7493 c.192C>T synonymous_variant 0.24
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8445 p.Arg382Gly missense_variant 0.21
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 620407 p.Pro173Ala missense_variant 0.24
rpoB 759831 p.Thr9Pro missense_variant 0.27
rpoC 762836 c.-534C>G upstream_gene_variant 0.34
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 0.99
mmpL5 777399 p.Thr361Arg missense_variant 0.15
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1417140 p.Ala70Ser missense_variant 1.0
embR 1417501 c.-154A>C upstream_gene_variant 0.27
atpE 1461019 c.-26C>A upstream_gene_variant 0.21
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474380 n.723G>T non_coding_transcript_exon_variant 0.2
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.17
fabG1 1673249 c.-191C>T upstream_gene_variant 1.0
fabG1 1673449 p.Thr4Pro missense_variant 0.35
inhA 1674892 p.Asn231Asp missense_variant 0.18
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169320 p.Leu431Phe missense_variant 0.18
PPE35 2169866 c.747G>C synonymous_variant 0.4
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.31
eis 2715586 c.-254G>C upstream_gene_variant 0.59
ahpC 2725954 c.-239C>T upstream_gene_variant 0.27
folC 2747022 p.Val193Ile missense_variant 0.99
pepQ 2859381 c.1038C>G synonymous_variant 0.17
Rv2752c 3064552 p.Arg547Pro missense_variant 0.2
Rv2752c 3064741 p.Gly484Ala missense_variant 0.28
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339550 p.Gly145Trp missense_variant 0.16
Rv3083 3448894 p.Tyr131Asp missense_variant 1.0
Rv3083 3449642 p.Asn380Ser missense_variant 0.99
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiA 3641164 p.Ile208Val missense_variant 1.0
fbiB 3641955 p.Gly141Arg missense_variant 0.26
fbiB 3642734 c.1200G>C synonymous_variant 0.23
ddn 3987013 p.Gly57Ala missense_variant 0.2
clpC1 4038857 c.1848C>A synonymous_variant 0.21
clpC1 4039363 p.Ala448Pro missense_variant 0.3
clpC1 4039932 p.Gly258Val missense_variant 0.21
embC 4241056 c.1194C>G synonymous_variant 0.28
embC 4241128 c.1266G>C synonymous_variant 0.2
embC 4241429 p.Phe523Val missense_variant 0.47
embC 4241456 p.Ala532Pro missense_variant 0.37
embC 4242476 p.Pro872Ala missense_variant 0.19
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.3
aftB 4268861 c.-25T>C upstream_gene_variant 1.0
ubiA 4269529 p.Ala102Gly missense_variant 0.19
ethA 4327672 c.-199G>A upstream_gene_variant 0.32
whiB6 4338595 c.-75delG upstream_gene_variant 1.0