TB-Profiler result

Run: ERR2503406
Summary

Run ID: ERR2503406

Sample name:

Date: 31-03-2023 18:26:21

Number of reads: 385148

Percentage reads mapped: 99.62

Strain: lineage4.3.3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.3 Euro-American (LAM) LAM;T RD115 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8040 p.Gly247Ser missense_variant 1.0
gyrA 8786 c.1485T>A synonymous_variant 0.1
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 490932 p.His50Gln missense_variant 0.14
rpoC 764983 c.1614T>A synonymous_variant 0.11
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
fabG1 1673837 p.Gly133Asp missense_variant 0.18
rpsA 1834836 p.Met432Thr missense_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2156196 c.-85C>T upstream_gene_variant 1.0
PPE35 2169394 p.Ala407Thr missense_variant 0.11
PPE35 2169397 p.Gly406Ser missense_variant 0.11
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518919 p.Gly269Ser missense_variant 1.0
eis 2715391 c.-59A>T upstream_gene_variant 0.12
ahpC 2726524 p.Leu111Pro missense_variant 0.12
folC 2746340 p.Ala420Val missense_variant 1.0
folC 2747116 c.483G>A synonymous_variant 0.13
ribD 2987308 p.Ala157Val missense_variant 0.16
thyA 3073685 p.Val263Leu missense_variant 0.12
thyA 3073832 p.Glu214* stop_gained 0.14
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3641967 p.Ala145Thr missense_variant 0.18
alr 3841470 c.-50G>T upstream_gene_variant 0.11
clpC1 4038287 c.2418C>T synonymous_variant 1.0
clpC1 4038968 c.1737G>A synonymous_variant 1.0
clpC1 4039003 p.Asn568Asp missense_variant 0.12
embA 4242643 c.-590C>T upstream_gene_variant 1.0
aftB 4267196 c.1641C>T synonymous_variant 0.13
aftB 4268101 p.Ala246Thr missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0