TB-Profiler result

Run: ERR2510768

Summary

Run ID: ERR2510768

Sample name:

Date: 20-10-2023 06:30:00

Number of reads: 1396862

Percentage reads mapped: 96.63

Strain: lineage4.8

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 575891 p.Ala182Thr missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.31
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.36
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.37
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.37
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.38
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.34
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.45
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.33
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.33
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.33
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.33
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.33
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.27
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.26
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.32
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.37
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.4
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.42
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.32
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4242928 c.-305A>G upstream_gene_variant 1.0
embB 4247595 p.Cys361Ser missense_variant 1.0
aftB 4268040 p.Leu266Pro missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0