TB-Profiler result

Run: ERR2514913
Summary

Run ID: ERR2514913

Sample name:

Date: 31-03-2023 20:38:20

Number of reads: 357378

Percentage reads mapped: 99.25

Strain:

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
ethA 4326292 c.1181delA frameshift_variant 0.2 ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 759620 c.-187A>C upstream_gene_variant 0.22
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 765260 p.Ala631Thr missense_variant 0.12
rpoC 765806 p.Gln813Lys missense_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303380 c.450T>C synonymous_variant 0.13
Rv1258c 1407423 c.-85_-84dupAC upstream_gene_variant 0.25
atpE 1460978 c.-67C>A upstream_gene_variant 0.5
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917816 c.-124G>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102538 p.Lys169Gln missense_variant 0.29
ndh 2103225 c.-183A>C upstream_gene_variant 0.6
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168681 p.Phe644Leu missense_variant 0.2
Rv1979c 2221732 p.Pro478Gln missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
kasA 2518406 p.Ala98Ser missense_variant 0.29
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
thyA 3073921 p.Leu184Pro missense_variant 0.2
thyA 3074064 c.408C>A synonymous_variant 0.2
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087231 p.Gly138Cys missense_variant 0.12
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474298 p.Asp98His missense_variant 0.5
Rv3236c 3612997 c.120T>G synonymous_variant 0.15
fbiA 3641476 p.Asp312Asn missense_variant 0.14
ddn 3987105 p.Trp88Arg missense_variant 1.0
clpC1 4040062 p.Ile215Val missense_variant 1.0
clpC1 4040256 c.446_448dupAGG conservative_inframe_insertion 0.18
embC 4242075 p.Arg738Gln missense_variant 1.0
embC 4242326 p.Thr822Ser missense_variant 0.2
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244977 p.Gly582Val missense_variant 0.17
aftB 4267352 c.1485C>T synonymous_variant 1.0
aftB 4267509 p.Asn443Ser missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338710 c.-190delC upstream_gene_variant 0.13
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407763 p.Lys147Ile missense_variant 0.25
gid 4407796 p.Ser136Leu missense_variant 0.29