TB-Profiler result

Run: ERR2514943

Summary

Run ID: ERR2514943

Sample name:

Date: 20-10-2023 11:27:03

Number of reads: 2261850

Percentage reads mapped: 93.3

Strain: lineage4.8

Drug-resistance: Sensitive


Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.28
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.56
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.36
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.36
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.35
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.42
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.35
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.33
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.33
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.35
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.48
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.39
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.39
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.52
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.44
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.47
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.3
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.35
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.35
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.38
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.45
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.45
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.45
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.45
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.43
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.43
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.54
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.47
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.44
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.44
rrl 1474658 n.1001A>G non_coding_transcript_exon_variant 0.55
rrl 1474753 n.1096_1097delACinsG non_coding_transcript_exon_variant 0.67
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.67
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.64
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.55
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.5
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.43
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.52
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.42
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 0.4
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.4
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.4
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.35
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102055 p.Pro330Ser missense_variant 1.0
PPE35 2168076 p.Thr846Met missense_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
alr 3841256 c.165C>T synonymous_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0