TB-Profiler result

Run: ERR2515026
Summary

Run ID: ERR2515026

Sample name:

Date: 31-03-2023 20:42:37

Number of reads: 752084

Percentage reads mapped: 99.01

Strain: lineage4.3.2

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.2 Euro-American (LAM) LAM3 None 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 490776 c.-7A>G upstream_gene_variant 0.13
rpoB 760708 p.Asp301Val missense_variant 0.15
rpoB 760790 c.984C>T synonymous_variant 0.18
rpoB 760843 p.Gln346Pro missense_variant 0.11
rpoB 760925 c.1119T>C synonymous_variant 0.1
rpoB 760928 c.1122G>C synonymous_variant 0.1
rpoB 760931 c.1125C>G synonymous_variant 0.1
rpoB 760934 c.1128C>T synonymous_variant 0.1
rpoB 760946 c.1140A>G synonymous_variant 0.1
rpoB 760982 c.1176G>C synonymous_variant 0.11
rpoB 760985 c.1179G>C synonymous_variant 0.12
rpoB 760991 c.1185G>C synonymous_variant 0.14
rpoB 761006 c.1200C>G synonymous_variant 0.14
rpoC 763354 c.-16G>T upstream_gene_variant 0.11
rpoC 764995 c.1626C>G synonymous_variant 1.0
rpoC 766106 p.Asp913Tyr missense_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304998 p.Trp690Arg missense_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 1.0
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 1.0
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 1.0
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 1.0
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 1.0
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 1.0
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 1.0
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 1.0
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 1.0
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.5
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.57
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.57
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.43
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.43
rrs 1473291 n.1446G>C non_coding_transcript_exon_variant 0.33
rrs 1473294 n.1449A>G non_coding_transcript_exon_variant 0.33
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.33
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.33
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.33
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.6
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.6
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.43
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.43
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.43
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.4
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918382 p.Val148Ala missense_variant 0.1
PPE35 2168176 p.Gln813Glu missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ribD 2987458 c.620_621insCAC disruptive_inframe_insertion 0.12
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612361 c.756C>T synonymous_variant 1.0
alr 3841546 c.-126C>A upstream_gene_variant 0.11
clpC1 4038287 c.2418C>T synonymous_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4249788 p.Gly1092Asp missense_variant 0.11
aftB 4267035 p.Arg601Leu missense_variant 0.11
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0