TB-Profiler result

Run: ERR270709

Summary

Run ID: ERR270709

Sample name:

Date: 31-03-2023 23:18:06

Number of reads: 4002304

Percentage reads mapped: 99.74

Strain: lineage4.9

Drug-resistance: HR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
fabG1 1673432 c.-8T>C upstream_gene_variant 1.0 isoniazid, ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170385 c.228G>A synonymous_variant 0.18
thyA 3073806 c.666C>G synonymous_variant 0.28
fbiD 3339733 p.Ala206Pro missense_variant 0.11
rpoA 3878590 c.-83G>C upstream_gene_variant 0.1
rpoA 3878601 c.-94C>G upstream_gene_variant 0.2
clpC1 4038857 c.1848C>A synonymous_variant 0.3
embC 4240906 c.1044C>A synonymous_variant 0.99
embC 4242425 p.Arg855Gly missense_variant 0.44
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407956 p.Arg83Gly missense_variant 1.0