TB-Profiler result

Run: ERR4132443
Summary

Run ID: ERR4132443

Sample name:

Date: 01-04-2023 04:30:16

Number of reads: 470661

Percentage reads mapped: 99.03

Strain: lineage4.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9426 p.Asp709Asn missense_variant 0.11
fgd1 491591 p.Lys270Met missense_variant 1.0
rpoB 759615 c.-192A>C upstream_gene_variant 0.36
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 764263 c.894G>A synonymous_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 1.0
rpoC 765630 p.Asp754Val missense_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776002 p.Leu827Met missense_variant 0.22
mmpL5 776028 p.Leu818Arg missense_variant 0.22
mmpL5 777320 c.1161C>G synonymous_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303574 p.Leu215Pro missense_variant 0.22
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
fabG1 1673945 p.Arg169Leu missense_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2103225 c.-183A>C upstream_gene_variant 0.36
katG 2154057 c.2055C>T synonymous_variant 0.12
PPE35 2168371 p.Ala748Thr missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
kasA 2519140 c.1026G>C synonymous_variant 0.5
kasA 2519143 c.1029G>C synonymous_variant 0.4
ahpC 2726350 p.Trp53Leu missense_variant 0.22
folC 2746885 c.714C>A synonymous_variant 0.15
ribD 2987102 c.264G>T synonymous_variant 0.25
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448407 c.-97A>G upstream_gene_variant 0.25
Rv3083 3448410 c.-94A>T upstream_gene_variant 0.25
Rv3083 3449756 p.Tyr418Phe missense_variant 0.14
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474998 p.Gly331Asp missense_variant 0.15
whiB7 3568757 c.-78A>T upstream_gene_variant 0.25
whiB7 3568849 c.-170C>T upstream_gene_variant 0.2
Rv3236c 3611974 c.1143A>C synonymous_variant 1.0
fbiA 3640765 p.Pro75Thr missense_variant 0.14
fbiB 3642748 p.Ala405Asp missense_variant 0.22
alr 3841546 c.-126C>A upstream_gene_variant 0.2
panD 4044270 c.12G>A synonymous_variant 0.14
panD 4044337 c.-56G>T upstream_gene_variant 0.15
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embA 4245437 p.Met735Ile missense_variant 0.25
embB 4247068 c.555T>C synonymous_variant 0.4
embB 4249155 p.Gly881Val missense_variant 0.33
aftB 4267130 c.1707C>G synonymous_variant 0.14
aftB 4268158 p.Phe227Val missense_variant 1.0
ethA 4327968 c.-495C>A upstream_gene_variant 0.15
whiB6 4338595 c.-75delG upstream_gene_variant 1.0