TB-Profiler result

Run: ERR4407447

Summary

Run ID: ERR4407447

Sample name:

Date: 01-04-2023 05:44:19

Number of reads: 529392

Percentage reads mapped: 86.89

Strain: lineage4.3.1

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.1 Euro-American (LAM) LAM9 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576290 p.Leu315Ile missense_variant 0.13
rpoB 760411 p.Arg202His missense_variant 0.11
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 779258 p.Arg90His missense_variant 0.1
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1407039 p.Val101Asp missense_variant 0.14
embR 1416204 p.Ala382Thr missense_variant 0.11
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170066 p.Ala183Thr missense_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv2752c 3066292 c.-102dupC upstream_gene_variant 0.17
thyX 3067490 c.456C>T synonymous_variant 0.12
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086727 c.-93G>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448588 p.Asp29Tyr missense_variant 0.12
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612922 c.195T>G synonymous_variant 0.11
fbiB 3642807 p.Ala425Ser missense_variant 0.12
clpC1 4038287 c.2418C>T synonymous_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4249588 c.3075C>T synonymous_variant 0.18
embB 4249701 p.Ser1063Tyr missense_variant 0.1
embB 4249781 c.3269delC frameshift_variant 0.11
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0