TB-Profiler result

Run: ERR4407460
Summary

Run ID: ERR4407460

Sample name:

Date: 01-04-2023 05:45:00

Number of reads: 355238

Percentage reads mapped: 99.57

Strain: lineage4.1.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6591 p.Arg451Leu missense_variant 0.14
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8703 p.Ile468Val missense_variant 0.12
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 1.0
mshA 575176 c.-172T>G upstream_gene_variant 0.18
mshA 575679 p.Asn111Ser missense_variant 1.0
mshA 575947 c.600G>A synonymous_variant 0.12
ccsA 620748 c.858T>G synonymous_variant 0.36
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoB 760563 c.757C>A synonymous_variant 0.12
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpS5 778871 p.Leu12Pro missense_variant 0.13
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406917 p.Ile142Val missense_variant 0.1
atpE 1460979 c.-66G>A upstream_gene_variant 0.11
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2155079 p.Lys345* stop_gained 0.12
katG 2155855 p.Thr86Ser missense_variant 0.13
Rv1979c 2221928 p.Thr413Ala missense_variant 0.11
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
eis 2714360 p.Asp325Asn missense_variant 0.15
pepQ 2859393 c.1026G>A synonymous_variant 0.13
Rv2752c 3064747 p.Gly482Asp missense_variant 0.12
thyA 3074361 c.111T>C synonymous_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339273 c.156T>G synonymous_variant 0.2
fbiD 3339500 c.385dupA frameshift_variant 0.17
Rv3083 3448918 p.Cys139Arg missense_variant 0.15
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3878555 c.-48G>C upstream_gene_variant 1.0
embC 4241836 c.1974A>T synonymous_variant 0.18
embC 4242220 c.2358A>C synonymous_variant 0.22
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
ubiA 4269022 p.Ala271Val missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0