TB-Profiler result

Run: ERR4553475
Summary

Run ID: ERR4553475

Sample name:

Date: 01-04-2023 06:11:04

Number of reads: 1584464

Percentage reads mapped: 99.84

Strain: lineage4.9

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Trp missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
fgd1 491377 p.Gly199Arg missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.27
rpoB 761969 c.2163G>A synonymous_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918089 c.150C>G synonymous_variant 1.0
PPE35 2170763 c.-151C>T upstream_gene_variant 1.0
embB 4248851 c.2338C>T synonymous_variant 1.0
ethA 4326977 p.His166Pro missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0