TB-Profiler result

Run: ERR4553812

Summary

Run ID: ERR4553812

Sample name:

Date: 01-04-2023 06:21:31

Number of reads: 1741548

Percentage reads mapped: 99.8

Strain: lineage4.9

Drug-resistance: MDR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Trp missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289089 p.His51Arg missense_variant 0.11 pyrazinamide
gid 4407587 p.Arg206* stop_gained 1.0 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.26
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.16
ald 3087818 p.Cys333Trp missense_variant 0.16
fbiD 3339734 p.Ala206Gly missense_variant 0.38
whiB7 3568425 c.255T>G synonymous_variant 0.24
embC 4240409 p.Pro183Ala missense_variant 0.15
embA 4243699 p.Pro156Leu missense_variant 0.98
embA 4244697 p.Val489Ile missense_variant 1.0
embB 4247468 p.Tyr319Asp missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407711 c.492C>G synonymous_variant 1.0