TB-Profiler result

Run: ERR4800644
Summary

Run ID: ERR4800644

Sample name:

Date: 01-04-2023 09:57:56

Number of reads: 2944907

Percentage reads mapped: 99.68

Strain: lineage4.9

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2155168 p.Ser315Thr missense_variant 0.96 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.22
mshA 576482 p.Val379Leu missense_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472027 n.182C>T non_coding_transcript_exon_variant 0.89
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.18
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518187 p.Ile25Leu missense_variant 0.94
thyA 3073696 p.Ala259Val missense_variant 0.93
fbiD 3339734 p.Ala206Gly missense_variant 0.24
rpoA 3878637 c.-130G>C upstream_gene_variant 0.23
embB 4246584 p.Arg24Pro missense_variant 0.33
ethA 4326976 p.His166Gln missense_variant 0.95
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407790 c.412delG frameshift_variant 0.96