TB-Profiler result

Run: ERR4800675
Summary

Run ID: ERR4800675

Sample name:

Date: 01-04-2023 09:58:57

Number of reads: 2889806

Percentage reads mapped: 99.68

Strain: lineage4.5

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.5 Euro-American H;T RD122 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761127 p.Ser441Gln missense_variant 0.97 rifampicin
fabG1 1673423 c.-17G>T upstream_gene_variant 0.99 isoniazid, ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7892 c.591G>A synonymous_variant 0.98
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 620029 c.139C>T synonymous_variant 0.98
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302780 c.-151G>T upstream_gene_variant 1.0
fbiC 1302905 c.-26T>G upstream_gene_variant 0.99
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154543 c.1569G>A synonymous_variant 0.97
PPE35 2170568 p.Ile15Met missense_variant 0.93
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568853 c.-175_-174insT upstream_gene_variant 0.95
rpoA 3878575 c.-68C>T upstream_gene_variant 1.0
clpC1 4038318 p.Pro796Leu missense_variant 0.95
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244948 c.1716G>A synonymous_variant 1.0
embB 4247010 p.Asp166Val missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0