TB-Profiler result

Run: ERR4811332
Summary

Run ID: ERR4811332

Sample name:

Date: 01-04-2023 11:16:50

Number of reads: 13761568

Percentage reads mapped: 99.38

Strain: lineage4.5

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.5 Euro-American H;T RD122 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761089 p.Ser428Ile missense_variant 0.99 rifampicin
rpoB 761110 p.Asp435Gly missense_variant 1.0 rifampicin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7892 c.591G>A synonymous_variant 0.99
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 620029 c.139C>T synonymous_variant 0.99
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1833734 p.Ala65Thr missense_variant 0.99
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170568 p.Ile15Met missense_variant 0.98
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714211 c.1122G>A synonymous_variant 1.0
folC 2747478 p.Thr41Pro missense_variant 0.98
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475279 p.Val425Met missense_variant 0.99
fbiA 3641438 p.Asp299Ala missense_variant 0.96
rpoA 3878575 c.-68C>T upstream_gene_variant 1.0
clpC1 4038318 p.Pro796Leu missense_variant 0.99
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4245372 p.Pro714Ser missense_variant 0.99
ethR 4327552 p.Thr2Ala missense_variant 0.99
whiB6 4338370 c.150_151dupGA frameshift_variant 0.11
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338649 c.-128C>T upstream_gene_variant 1.0