TB-Profiler result

Run: ERR4811908
Summary

Run ID: ERR4811908

Sample name:

Date: 01-04-2023 11:44:47

Number of reads: 681184

Percentage reads mapped: 99.42

Strain: lineage4.4.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.4 Euro-American S;T None 1.0
lineage4.4.1 Euro-American (S-type) S;T None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 490820 p.Glu13Gly missense_variant 0.14
rpoB 760979 c.1173G>A synonymous_variant 0.12
rpoB 762804 p.Gly1000Cys missense_variant 0.11
rpoC 766463 p.Gln1032* stop_gained 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304059 p.Leu377Met missense_variant 0.13
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1475227 n.1572dupA non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102990 p.Val18Ala missense_variant 1.0
katG 2154483 c.1629C>T synonymous_variant 0.11
PPE35 2169840 p.Gly258Asp missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pepQ 2859466 p.Ala318Gly missense_variant 0.11
pepQ 2860286 p.Val45Leu missense_variant 1.0
Rv2752c 3066389 c.-198C>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448608 c.105G>A synonymous_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612568 c.549G>T synonymous_variant 0.11
fbiA 3641480 p.Pro313Gln missense_variant 0.13
panD 4044003 p.Met93Ile missense_variant 0.11
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4249021 c.2508G>T synonymous_variant 0.29
whiB6 4338460 p.Met21Thr missense_variant 1.0
whiB6 4338520 c.2T>C start_lost 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0