TB-Profiler result

Run: ERR4812086
Summary

Run ID: ERR4812086

Sample name:

Date: 01-04-2023 11:51:19

Number of reads: 3105027

Percentage reads mapped: 99.48

Strain: lineage4.1.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 0.99
mshA 575679 p.Asn111Ser missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.34
mshA 576111 p.Ala255Gly missense_variant 0.25
mshA 576603 p.Arg419Leu missense_variant 0.15
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304032 p.Glu368* stop_gained 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918158 c.219G>T synonymous_variant 0.12
PPE35 2170304 c.309G>T synonymous_variant 0.67
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
kasA 2519055 p.Ala314Val missense_variant 0.29
pepQ 2859620 p.Gly267Cys missense_variant 0.12
pepQ 2859632 p.Ala263Ser missense_variant 0.11
thyA 3073796 p.Pro226Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612846 p.Pro91Ser missense_variant 1.0
rpoA 3878619 c.-112A>C upstream_gene_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embA 4244266 p.Arg345Leu missense_variant 0.25
embA 4244306 c.1074G>T synonymous_variant 0.25
embA 4244627 c.1395G>T synonymous_variant 0.14
embB 4246584 p.Arg24Pro missense_variant 0.17
embB 4247024 p.Pro171Ser missense_variant 0.17
whiB6 4338595 c.-75delG upstream_gene_variant 1.0