TB-Profiler result

Run: ERR4812834
Summary

Run ID: ERR4812834

Sample name:

Date: 01-04-2023 12:22:14

Number of reads: 5037944

Percentage reads mapped: 99.35

Strain:

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 1.0
mshA 576114 p.Arg256Pro missense_variant 0.24
mshA 576338 p.Gln331Lys missense_variant 0.11
rpoB 760115 c.309C>T synonymous_variant 0.97
rpoB 760555 p.Glu250Gly missense_variant 0.99
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776275 p.Ala736Ser missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302920 c.-11G>A upstream_gene_variant 1.0
Rv1258c 1406973 p.Ala123Asp missense_variant 0.22
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102244 c.799C>A synonymous_variant 0.22
ndh 2102370 p.Gly225Cys missense_variant 0.29
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 0.99
kasA 2518593 p.Ala160Asp missense_variant 0.11
kasA 2518799 p.Pro229Thr missense_variant 0.17
kasA 2518828 c.714G>A synonymous_variant 0.13
eis 2714814 c.519C>T synonymous_variant 0.2
folC 2746277 p.Asp441Gly missense_variant 1.0
folC 2746531 c.1068G>A synonymous_variant 0.14
folC 2746783 c.816C>A synonymous_variant 0.17
pepQ 2859617 p.Ala268Ser missense_variant 1.0
pepQ 2859825 c.594C>T synonymous_variant 0.13
ribD 2987379 p.Gln181* stop_gained 0.2
Rv2752c 3067012 c.-821C>A upstream_gene_variant 0.67
Rv2752c 3067065 c.-874G>T upstream_gene_variant 0.33
Rv2752c 3067083 c.-892C>A upstream_gene_variant 0.25
Rv2752c 3067098 c.-907A>T upstream_gene_variant 0.25
thyX 3067430 c.516C>A synonymous_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339079 c.-39G>C upstream_gene_variant 0.13
fbiD 3339531 p.Ser138Arg missense_variant 0.13
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612093 p.Gly342Trp missense_variant 0.14
fbiB 3641274 c.-261G>T upstream_gene_variant 0.22
fbiB 3641589 p.Gly19Trp missense_variant 0.15
fbiB 3641594 c.60G>A synonymous_variant 1.0
embC 4240381 c.519G>A synonymous_variant 0.15
embC 4242362 p.Gly834Ser missense_variant 0.67
embC 4242803 p.Val981Leu missense_variant 1.0
embA 4243673 c.441C>A synonymous_variant 0.4
embA 4243716 p.Leu162Met missense_variant 0.17
embA 4243960 p.Arg243Leu missense_variant 0.5
embA 4244907 p.Gly559Ser missense_variant 0.33
embB 4245665 c.-849C>T upstream_gene_variant 0.12
embA 4245834 p.Leu868Met missense_variant 0.25
embA 4245840 p.Val870Leu missense_variant 0.22
embB 4247246 p.Arg245Trp missense_variant 0.29
aftB 4267591 p.Gln416* stop_gained 0.2
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408242 c.-40T>C upstream_gene_variant 0.11
gid 4408279 c.-77G>A upstream_gene_variant 0.12