TB-Profiler result

Run: ERR4813051
Summary

Run ID: ERR4813051

Sample name:

Date: 01-04-2023 12:30:17

Number of reads: 532590

Percentage reads mapped: 99.27

Strain: lineage4

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6052 p.Ile271Met missense_variant 1.0
gyrB 7221 p.Ser661Thr missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 490937 p.Pro52Gln missense_variant 0.2
rpoB 760996 p.Arg397Leu missense_variant 0.12
rpoC 762482 c.-888C>A upstream_gene_variant 0.18
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1416699 p.Leu217Val missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1833398 c.-144G>T upstream_gene_variant 0.18
ndh 2102005 c.1038G>A synonymous_variant 0.13
katG 2155518 p.Trp198Cys missense_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473984 c.-23G>T upstream_gene_variant 0.17
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3877746 c.762G>T synonymous_variant 0.12
rpoA 3878304 c.204G>T synonymous_variant 0.11
clpC1 4038584 c.2121G>T synonymous_variant 0.13
embC 4240191 p.Pro110Leu missense_variant 0.22
embC 4242747 p.Pro962Gln missense_variant 0.67
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4247485 c.972C>A synonymous_variant 0.13
embB 4249408 c.2895G>A synonymous_variant 1.0
ubiA 4269238 p.Ala199Asp missense_variant 0.12
ethA 4326116 p.Thr453Ile missense_variant 1.0
ethA 4328237 c.-764C>A upstream_gene_variant 0.11
whiB6 4338595 c.-75delG upstream_gene_variant 1.0