TB-Profiler result

Run: ERR4813321
Summary

Run ID: ERR4813321

Sample name:

Date: 2024-04-15T02:02:05.808881

Number of reads: 225708

Percentage reads mapped: 99.51

Median coverage: 7.0

Strain: lineage4.3.3;lineage4.3.4.2

Spoligotype:

Drug-resistance: Sensitive

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.25
lineage4 Euro-American None 1.0
lineage4.3.3 Euro-American (LAM) RD115 0.17
lineage4.3.4 Euro-American (LAM) RD174 0.19
lineage4.3.4.2 Euro-American (LAM) RD174 0.06
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 8040 p.Gly247Ser missense_variant 0.62 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
katG 2155017 c.1095G>A synonymous_variant 0.55 isoniazid Not assoc w R - Interim
thyA 3073868 p.Thr202Ala missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407720 c.483C>G synonymous_variant 0.55 streptomycin Not assoc w R - Interim