TB-Profiler result

Run: ERR4813514
Summary

Run ID: ERR4813514

Sample name:

Date: 01-04-2023 12:48:14

Number of reads: 1388738

Percentage reads mapped: 98.79

Strain: lineage4.1.1

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 0.92
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6052 p.Ile271Met missense_variant 0.8
gyrB 7221 p.Ser661Thr missense_variant 0.95
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.24
mshA 576114 p.Arg256Pro missense_variant 0.21
rpoC 764995 c.1626C>G synonymous_variant 0.17
rpoC 765150 p.Gly594Glu missense_variant 0.84
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 778457 c.-533C>T upstream_gene_variant 0.15
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1416699 p.Leu217Val missense_variant 0.88
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471951 n.106G>T non_coding_transcript_exon_variant 0.11
rrl 1475625 n.1968G>A non_coding_transcript_exon_variant 0.14
tlyA 1917830 c.-110C>T upstream_gene_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv2752c 3065952 c.240C>G synonymous_variant 1.0
Rv2752c 3067082 c.-891C>A upstream_gene_variant 0.18
thyA 3073868 p.Thr202Ala missense_variant 0.12
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339051 c.-67C>A upstream_gene_variant 0.2
fbiD 3339415 p.Glu100* stop_gained 0.12
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiA 3641420 p.Gly293Asp missense_variant 0.13
fbiB 3642554 c.1020C>A synonymous_variant 0.13
fbiB 3642616 p.Pro361His missense_variant 0.17
rpoA 3878613 c.-106A>C upstream_gene_variant 0.33
ddn 3987009 p.Thr56Pro missense_variant 0.74
panD 4044395 c.-114C>T upstream_gene_variant 0.11
embC 4241922 p.Gly687Glu missense_variant 0.12
embC 4242182 p.Ala774Ser missense_variant 0.21
embC 4242803 p.Val981Leu missense_variant 0.77
embA 4244639 c.1407G>A synonymous_variant 0.67
embB 4245557 c.-957G>A upstream_gene_variant 0.11
embA 4245744 p.Pro838Thr missense_variant 0.18
embB 4246584 p.Arg24Pro missense_variant 0.38
embB 4247028 p.Leu172Arg missense_variant 0.29
embB 4248830 p.Ser773Pro missense_variant 0.18
embB 4249408 c.2895G>A synonymous_variant 0.88
ethA 4326497 p.Arg326Leu missense_variant 0.93
whiB6 4338302 p.Gly74Trp missense_variant 0.15
whiB6 4338312 c.210G>T synonymous_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0