TB-Profiler result

Run: ERR4813519

Summary

Run ID: ERR4813519

Sample name:

Date: 01-04-2023 12:48:27

Number of reads: 1604662

Percentage reads mapped: 99.1

Strain:

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7461 c.163delG frameshift_variant 0.18
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 0.97
mshA 575542 c.195C>T synonymous_variant 0.22
mshA 575679 p.Asn111Ser missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.4
rpoB 760115 c.309C>T synonymous_variant 0.99
rpoC 765150 p.Gly594Glu missense_variant 0.93
rpoC 766561 c.3192C>A synonymous_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917917 c.-23G>A upstream_gene_variant 0.33
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918486 p.Pro183Ser missense_variant 0.17
katG 2155328 p.Thr262Ala missense_variant 0.76
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
kasA 2518735 c.621C>T synonymous_variant 0.33
folC 2746240 c.1359C>T synonymous_variant 0.12
folC 2747514 p.Gln29Lys missense_variant 0.12
Rv2752c 3066351 c.-160G>C upstream_gene_variant 0.11
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087426 p.Lys203Gln missense_variant 0.96
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiA 3641084 p.Pro181Leu missense_variant 0.1
embC 4241145 p.Ala428Asp missense_variant 0.25
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4246558 c.45G>T synonymous_variant 0.33
embB 4246584 p.Arg24Pro missense_variant 0.3
embB 4246968 p.Ser152Tyr missense_variant 0.2
embB 4247028 p.Leu172Arg missense_variant 0.4
embB 4247207 p.Ala232Thr missense_variant 0.25
aftB 4267610 c.1227C>T synonymous_variant 0.12
aftB 4267855 c.982C>A synonymous_variant 0.67
aftB 4268047 p.Tyr264Asp missense_variant 0.22
aftB 4268222 c.615G>T synonymous_variant 0.12
aftB 4268435 p.Phe134Leu missense_variant 0.22
aftB 4268696 c.141G>A synonymous_variant 0.11
ubiA 4269719 p.Ala39Ser missense_variant 0.11
whiB6 4338595 c.-75delG upstream_gene_variant 1.0