TB-Profiler result

Run: ERR4814324
Summary

Run ID: ERR4814324

Sample name:

Date: 01-04-2023 13:13:44

Number of reads: 714172

Percentage reads mapped: 99.28

Strain: lineage4.1.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 0.99
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5321 p.Lys28Glu missense_variant 0.1
gyrB 6241 p.Asp334Glu missense_variant 0.13
gyrB 6545 p.Gly436Cys missense_variant 0.12
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7648 p.Phe116Ser missense_variant 0.17
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491211 p.Trp143Cys missense_variant 0.12
fgd1 491591 p.Lys270Met missense_variant 1.0
mshA 575679 p.Asn111Ser missense_variant 1.0
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 1.0
rpoC 765301 c.1932C>T synonymous_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302821 c.-110G>A upstream_gene_variant 0.11
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834001 p.Glu154* stop_gained 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169025 p.Pro530Thr missense_variant 0.17
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
Rv2752c 3065205 c.987T>C synonymous_variant 0.12
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448726 p.Leu75Ile missense_variant 0.12
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612366 p.Leu251Val missense_variant 0.15
rpoA 3877638 c.870T>C synonymous_variant 0.13
rpoA 3877677 c.831G>C synonymous_variant 0.15
rpoA 3878401 p.Asn36Ile missense_variant 0.14
embC 4241560 c.1698C>A synonymous_variant 0.17
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4249766 p.Arg1085Ser missense_variant 0.15
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338676 c.-155T>C upstream_gene_variant 1.0