TB-Profiler result

Run: ERR4814905
Summary

Run ID: ERR4814905

Sample name:

Date: 20-10-2023 07:40:56

Number of reads: 14617352

Percentage reads mapped: 97.99

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 8933 c.1632G>A synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.13
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.14
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.16
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.12
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.12
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.24
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.29
rrs 1472123 n.278A>G non_coding_transcript_exon_variant 0.28
rrs 1472138 n.293C>A non_coding_transcript_exon_variant 0.2
rrs 1472147 n.302G>T non_coding_transcript_exon_variant 0.23
rrs 1472150 n.305T>G non_coding_transcript_exon_variant 0.39
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.25
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.12
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.29
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.24
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.33
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.29
rrs 1472431 n.586G>A non_coding_transcript_exon_variant 0.25
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.27
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.3
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.3
rrs 1472447 n.602C>T non_coding_transcript_exon_variant 0.3
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.3
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.42
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.4
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.43
rrs 1472484 n.639A>T non_coding_transcript_exon_variant 0.41
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.31
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.22
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.38
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.21
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.25
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.25
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.15
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.45
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.45
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.14
rrs 1472574 n.729T>A non_coding_transcript_exon_variant 0.18
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.37
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.44
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.19
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.43
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.43
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.24
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.22
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.34
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.38
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.31
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.27
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.21
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.19
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.27
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.47
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.11
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.58
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.42
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.17
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.28
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.33
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.2
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.2
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.14
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.14
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.18
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.26
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.32
rrs 1473202 n.1357C>T non_coding_transcript_exon_variant 0.2
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.12
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.3
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.22
rrs 1473282 n.1437_1438delCTinsTCA non_coding_transcript_exon_variant 0.2
rrs 1473287 n.1442_1448delCCTCGGGinsTCGTTT non_coding_transcript_exon_variant 0.23
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.22
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.12
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.64
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.82
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.86
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.6
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.46
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.86
rrl 1474542 n.885A>C non_coding_transcript_exon_variant 0.43
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.43
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.64
rrl 1475713 n.2056C>T non_coding_transcript_exon_variant 0.38
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.39
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.35
rrl 1475759 n.2102C>A non_coding_transcript_exon_variant 0.35
rrl 1475762 n.2105G>A non_coding_transcript_exon_variant 0.36
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.36
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.36
rrl 1475767 n.2110_2112delGGTinsTTGGTC non_coding_transcript_exon_variant 0.36
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.3
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.38
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.3
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.31
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.33
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.32
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.39
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.32
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.31
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.19
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.24
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.37
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.21
rrl 1476523 n.2867delC non_coding_transcript_exon_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0