TB-Profiler result

Run: ERR4815324
Summary

Run ID: ERR4815324

Sample name:

Date: 01-04-2023 13:48:03

Number of reads: 1594157

Percentage reads mapped: 99.74

Strain: lineage4.3.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.2 Euro-American (LAM) LAM3 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1473462 n.-196G>T upstream_gene_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168176 p.Gln813Glu missense_variant 1.0
PPE35 2169902 p.Leu237Phe missense_variant 0.18
PPE35 2169910 p.Asn235Tyr missense_variant 0.14
PPE35 2170048 p.Leu189Val missense_variant 0.14
PPE35 2170053 p.Thr187Ser missense_variant 0.14
PPE35 2170392 p.Gly74Ala missense_variant 0.1
PPE35 2170400 c.213G>C synonymous_variant 0.17
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519140 c.1026G>C synonymous_variant 0.16
kasA 2519143 c.1029G>C synonymous_variant 0.15
kasA 2519153 p.Ile347Val missense_variant 0.16
eis 2714998 p.Gly112Val missense_variant 0.11
ahpC 2726341 p.Val50Gly missense_variant 0.19
folC 2746607 p.Ala331Val missense_variant 0.14
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612361 c.756C>T synonymous_variant 1.0
fbiA 3640371 c.-172G>A upstream_gene_variant 1.0
alr 3841546 c.-126C>A upstream_gene_variant 0.23
clpC1 4038287 c.2418C>T synonymous_variant 1.0
clpC1 4038773 p.Asp644Glu missense_variant 0.12
clpC1 4038776 p.Glu643Asp missense_variant 0.11
clpC1 4039645 p.His354Asp missense_variant 0.11
embC 4242396 p.Pro845Gln missense_variant 0.12
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244939 p.Lys569Asn missense_variant 0.11
embB 4247470 c.957T>C synonymous_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0